Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study
Objective Microalbuminuria (MAU) has been described as a risk factor for metabolic syndrome (MetS). However, the association between MetS components with MAU and 24-hour urinary albumin excretion (UAE) has not been clearly explained in the general Chinese population. We aimed to analyse the associat...
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BMJ Publishing Group
2019-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/11/e031443.full |
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| author | Jing Wu Jixiang Ma Xiaorong Chen Liuxia Yan Xiaoning Cai Xiaolei Guo Yongqing Zhang |
| author_facet | Jing Wu Jixiang Ma Xiaorong Chen Liuxia Yan Xiaoning Cai Xiaolei Guo Yongqing Zhang |
| author_sort | Jing Wu |
| collection | DOAJ |
| description | Objective Microalbuminuria (MAU) has been described as a risk factor for metabolic syndrome (MetS). However, the association between MetS components with MAU and 24-hour urinary albumin excretion (UAE) has not been clearly explained in the general Chinese population. We aimed to analyse the associations between MAU and high–normal 24-hour UAE with MetS and its components.Design Cross-sectional observational study.Setting Four selected counties/districts in China’s Shandong and Jiangsu Provinces.Participants A total of 2261 participants aged 18–69 years were included in this study. Participants with missing physical examination data or incomplete urine collection were not included in the analysis.Results The prevalence of MAU was 9%, and the mean 24-hour UAE was 18 mg/d. The prevalence of MAU was significantly higher for the MetS, high blood pressure (BP), high triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL-C) and hyperglycaemia groups but not for the central obesity group. Both MAU and mean 24-hour UAE were significantly increased in association with a number of MetS components. The adjusted prevalence OR (POR) for MetS with MAU was 2.95 (95% CI 2.15 to 4.04) compared with those without MAU. MAU was significantly associated with three components of MetS: high BP (POR=1.86, 95% CI 1.31 to 2.64), high TG levels (POR=1.80, 95% CI 1.31 to 2.46) and hyperglycaemia (POR=1.84, 95% CI 1.34 to 2.53). No significant association between MAU and central obesity or low HDL-C was found. The presence of MetS gradually increased according to the normal-range 24-hour UAE quartiles: POR=1.00, POR=1.22, POR=1.14 and POR=2.02, respectively. Hyperglycaemia also increased significantly according to the normal-range 24-hour UAE quartiles.Conclusions MAU and elevated 24-hour UAE within the normal range were closely associated with MetS in the Chinese population, which may provide a basis for the development of early interventions to decrease the effects of MetS. |
| format | Article |
| id | doaj-art-d0baec92805940f4bcc652b5c110f3d8 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-d0baec92805940f4bcc652b5c110f3d82025-08-20T02:48:42ZengBMJ Publishing GroupBMJ Open2044-60552019-11-0191110.1136/bmjopen-2019-031443Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional studyJing Wu0Jixiang Ma1Xiaorong Chen2Liuxia Yan3Xiaoning Cai4Xiaolei Guo5Yongqing Zhang6National Center for Chronic and Non-Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China2 Office of NCD and Ageing Health Management, Chinese Center for Disease Control and Prevention, Beijing, ChinaDepartment of Colorectal Cancer Center, Sichuan University West China Hospital, Chengdu, Sichuan, China1 National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China1 National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaShandong Center for Disease Control and Prevention, Jinan, China1 Department of Emergency Medicine and West China School of Nursing, Disaster Medicine Center, West China Hospital, Sichuan University, Chengdu, People`s Republic of ChinaObjective Microalbuminuria (MAU) has been described as a risk factor for metabolic syndrome (MetS). However, the association between MetS components with MAU and 24-hour urinary albumin excretion (UAE) has not been clearly explained in the general Chinese population. We aimed to analyse the associations between MAU and high–normal 24-hour UAE with MetS and its components.Design Cross-sectional observational study.Setting Four selected counties/districts in China’s Shandong and Jiangsu Provinces.Participants A total of 2261 participants aged 18–69 years were included in this study. Participants with missing physical examination data or incomplete urine collection were not included in the analysis.Results The prevalence of MAU was 9%, and the mean 24-hour UAE was 18 mg/d. The prevalence of MAU was significantly higher for the MetS, high blood pressure (BP), high triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL-C) and hyperglycaemia groups but not for the central obesity group. Both MAU and mean 24-hour UAE were significantly increased in association with a number of MetS components. The adjusted prevalence OR (POR) for MetS with MAU was 2.95 (95% CI 2.15 to 4.04) compared with those without MAU. MAU was significantly associated with three components of MetS: high BP (POR=1.86, 95% CI 1.31 to 2.64), high TG levels (POR=1.80, 95% CI 1.31 to 2.46) and hyperglycaemia (POR=1.84, 95% CI 1.34 to 2.53). No significant association between MAU and central obesity or low HDL-C was found. The presence of MetS gradually increased according to the normal-range 24-hour UAE quartiles: POR=1.00, POR=1.22, POR=1.14 and POR=2.02, respectively. Hyperglycaemia also increased significantly according to the normal-range 24-hour UAE quartiles.Conclusions MAU and elevated 24-hour UAE within the normal range were closely associated with MetS in the Chinese population, which may provide a basis for the development of early interventions to decrease the effects of MetS.https://bmjopen.bmj.com/content/9/11/e031443.full |
| spellingShingle | Jing Wu Jixiang Ma Xiaorong Chen Liuxia Yan Xiaoning Cai Xiaolei Guo Yongqing Zhang Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study BMJ Open |
| title | Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study |
| title_full | Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study |
| title_fullStr | Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study |
| title_full_unstemmed | Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study |
| title_short | Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study |
| title_sort | association of microalbuminuria and high normal 24 hour urinary albumin excretion with metabolic syndrome and its components in the general chinese population cross sectional study |
| url | https://bmjopen.bmj.com/content/9/11/e031443.full |
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