Corneal trophic ulcer one week after topical diclofenac use
A 65-year-old woman operated on for cataract was discharged from hospital with a routine prescription including diclofenac. One week later she was diagnosed with corneal trophic ulcer in the operated eye. As the non-operated eye suffered from filamentary keratopathy, the hypothesis of a serious adve...
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| Language: | English |
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Termedia Publishing House
2023-11-01
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| Series: | Klinika Oczna |
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| Online Access: | https://www.termedia.pl/Corneal-trophic-ulcer-one-week-after-topical-diclofenac-use,124,51878,1,1.html |
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| author | Piotr Lasota |
| author_facet | Piotr Lasota |
| author_sort | Piotr Lasota |
| collection | DOAJ |
| description | A 65-year-old woman operated on for cataract was discharged from hospital with a routine prescription including diclofenac. One week later she was diagnosed with corneal trophic ulcer in the operated eye. As the non-operated eye suffered from filamentary keratopathy, the hypothesis of a serious adverse event due to diclofenac was considered. Diclofenac was stopped and intensive topical non-preservative tears were administered. No further melting was noticed and epithelialization of the cornea occurred. Diclofenac as a non-steroidal anti-inflammatory drug is known for its anesthetic action on the cornea. This effect contributes to aggravation of the pre-existing dry eye syndrome related to Sjögren syndrome (diagnosed a posteriori) with potential for corneal perforation. Therefore the prescription of diclofenac should be preceded by questioning the patient about the predisposing rheumatoid conditions and careful examination of the eye. |
| format | Article |
| id | doaj-art-d0b39ce205ea4cca9cf9dc3935936565 |
| institution | Kabale University |
| issn | 0023-2157 2719-3209 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Klinika Oczna |
| spelling | doaj-art-d0b39ce205ea4cca9cf9dc39359365652025-01-24T13:00:46ZengTermedia Publishing HouseKlinika Oczna0023-21572719-32092023-11-011261454710.5114/ko.2023.13311451878Corneal trophic ulcer one week after topical diclofenac usePiotr LasotaA 65-year-old woman operated on for cataract was discharged from hospital with a routine prescription including diclofenac. One week later she was diagnosed with corneal trophic ulcer in the operated eye. As the non-operated eye suffered from filamentary keratopathy, the hypothesis of a serious adverse event due to diclofenac was considered. Diclofenac was stopped and intensive topical non-preservative tears were administered. No further melting was noticed and epithelialization of the cornea occurred. Diclofenac as a non-steroidal anti-inflammatory drug is known for its anesthetic action on the cornea. This effect contributes to aggravation of the pre-existing dry eye syndrome related to Sjögren syndrome (diagnosed a posteriori) with potential for corneal perforation. Therefore the prescription of diclofenac should be preceded by questioning the patient about the predisposing rheumatoid conditions and careful examination of the eye.https://www.termedia.pl/Corneal-trophic-ulcer-one-week-after-topical-diclofenac-use,124,51878,1,1.htmldry eye syndrome corneal trophic ulcer postoperative topical diclofenac sjögren syndrome. |
| spellingShingle | Piotr Lasota Corneal trophic ulcer one week after topical diclofenac use Klinika Oczna dry eye syndrome corneal trophic ulcer postoperative topical diclofenac sjögren syndrome. |
| title | Corneal trophic ulcer one week after topical diclofenac use |
| title_full | Corneal trophic ulcer one week after topical diclofenac use |
| title_fullStr | Corneal trophic ulcer one week after topical diclofenac use |
| title_full_unstemmed | Corneal trophic ulcer one week after topical diclofenac use |
| title_short | Corneal trophic ulcer one week after topical diclofenac use |
| title_sort | corneal trophic ulcer one week after topical diclofenac use |
| topic | dry eye syndrome corneal trophic ulcer postoperative topical diclofenac sjögren syndrome. |
| url | https://www.termedia.pl/Corneal-trophic-ulcer-one-week-after-topical-diclofenac-use,124,51878,1,1.html |
| work_keys_str_mv | AT piotrlasota cornealtrophiculceroneweekaftertopicaldiclofenacuse |