Corneal trophic ulcer one week after topical diclofenac use
A 65-year-old woman operated on for cataract was discharged from hospital with a routine prescription including diclofenac. One week later she was diagnosed with corneal trophic ulcer in the operated eye. As the non-operated eye suffered from filamentary keratopathy, the hypothesis of a serious adve...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2023-11-01
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| Series: | Klinika Oczna |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Corneal-trophic-ulcer-one-week-after-topical-diclofenac-use,124,51878,1,1.html |
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| Summary: | A 65-year-old woman operated on for cataract was discharged from hospital with a routine prescription including diclofenac. One week later she was diagnosed with corneal trophic ulcer in the operated eye. As the non-operated eye suffered from filamentary keratopathy, the hypothesis of a serious adverse event due to diclofenac was considered. Diclofenac was stopped and intensive topical non-preservative tears were administered. No further melting was noticed and epithelialization of the cornea occurred. Diclofenac as a non-steroidal anti-inflammatory drug is known for its anesthetic action on the cornea. This effect contributes to aggravation of the pre-existing dry eye syndrome related to Sjögren syndrome (diagnosed a posteriori) with potential for corneal perforation. Therefore the prescription of diclofenac should be preceded by questioning the patient about the predisposing rheumatoid conditions and careful examination of the eye. |
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| ISSN: | 0023-2157 2719-3209 |