Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice

Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice

In the adult brain, newborn granule cells continuously integrate into the hippocampal circuits, and fine-tuning the regulation of this process is crucial for improving hippocampal function. Iron is an essential element for the development and functionality of the brain. Ferroportin 1 (Fpn1) is an ir...

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Bibliographic Details
Main Authors: Yiqian Ding, Shanshan Yao, Shuxin Guo, Wei Meng, Jie Li, Fudi Wang, Jianhua Zhang, Yan-Zhong Chang, Guofen Gao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research
Subjects:
Ferroportin 1
Neural stem cells
Hippocampal neurogenesis
Iron
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002038
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