Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional study
BackgroundNeonatal hyperbilirubinemia frequently leads to severe neurological damage. Although cranial ultrasound (CUS) is crucial for assessing neonatal brain injury, the association between red blood cell distribution width-coefficient of variation (RDW-CV), a marker of red blood cell size variabi...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1488731/full |
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| author | Hongjuan Wei Xin Chang Jin Wang |
| author_facet | Hongjuan Wei Xin Chang Jin Wang |
| author_sort | Hongjuan Wei |
| collection | DOAJ |
| description | BackgroundNeonatal hyperbilirubinemia frequently leads to severe neurological damage. Although cranial ultrasound (CUS) is crucial for assessing neonatal brain injury, the association between red blood cell distribution width-coefficient of variation (RDW-CV), a marker of red blood cell size variability, and cranial ultrasound abnormalities (CUAs) remains unclear.ObjectiveThe primary aim of this study was to explore the impact of RDW-CV on CUAs in neonatal hyperbilirubinemia and to elucidate the potential clinical implications of this relationship.MethodsThis retrospective cross-sectional study included 503 cases of neonatal hyperbilirubinemia at gestational age ≥35 weeks with available RDW-CV and CUS screening data at Nanjing Lishui People's Hospital. Multivariate logistic regression analysis and smooth curve fitting were used to estimate the association between RDW-CV and the risk of CUAs in neonatal hyperbilirubinemia.ResultsThis study found that the overall prevalence of CUAs in ultrasound images was 26.0%. Multivariate logistic regression analysis adjusted for risk factors revealed that a one-percent increase in RDW-CV increased the risk of CUAs by 23.0%. After conducting a sensitivity analysis of the three RDW-CV quantiles, the findings remained robust and consistent.ConclusionsThe study concluded that a higher RDW-CV was associated with a proportional increase in the risk of CUAs. These results demonstrate the importance of RDW-CV in neonatal hyperbilirubinemia. Clinicians should consider this association when managing patients with high RDW-CV. |
| format | Article |
| id | doaj-art-d0a56f1ef7db4041ac1d39637d575170 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-d0a56f1ef7db4041ac1d39637d5751702025-01-29T06:46:20ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14887311488731Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional studyHongjuan Wei0Xin Chang1Jin Wang2Department of Pediatric, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, ChinaDepartment of Ultrasound Medicine, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, ChinaDepartment of Ultrasound Medicine, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, ChinaBackgroundNeonatal hyperbilirubinemia frequently leads to severe neurological damage. Although cranial ultrasound (CUS) is crucial for assessing neonatal brain injury, the association between red blood cell distribution width-coefficient of variation (RDW-CV), a marker of red blood cell size variability, and cranial ultrasound abnormalities (CUAs) remains unclear.ObjectiveThe primary aim of this study was to explore the impact of RDW-CV on CUAs in neonatal hyperbilirubinemia and to elucidate the potential clinical implications of this relationship.MethodsThis retrospective cross-sectional study included 503 cases of neonatal hyperbilirubinemia at gestational age ≥35 weeks with available RDW-CV and CUS screening data at Nanjing Lishui People's Hospital. Multivariate logistic regression analysis and smooth curve fitting were used to estimate the association between RDW-CV and the risk of CUAs in neonatal hyperbilirubinemia.ResultsThis study found that the overall prevalence of CUAs in ultrasound images was 26.0%. Multivariate logistic regression analysis adjusted for risk factors revealed that a one-percent increase in RDW-CV increased the risk of CUAs by 23.0%. After conducting a sensitivity analysis of the three RDW-CV quantiles, the findings remained robust and consistent.ConclusionsThe study concluded that a higher RDW-CV was associated with a proportional increase in the risk of CUAs. These results demonstrate the importance of RDW-CV in neonatal hyperbilirubinemia. Clinicians should consider this association when managing patients with high RDW-CV.https://www.frontiersin.org/articles/10.3389/fped.2024.1488731/fullcranialred blood cell distribution widthneonatal hyperbilirubinemiaultrasonographyneuroimaging |
| spellingShingle | Hongjuan Wei Xin Chang Jin Wang Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional study Frontiers in Pediatrics cranial red blood cell distribution width neonatal hyperbilirubinemia ultrasonography neuroimaging |
| title | Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional study |
| title_full | Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional study |
| title_fullStr | Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional study |
| title_full_unstemmed | Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional study |
| title_short | Association of red blood cell distribution width–coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia: a retrospective cross-sectional study |
| title_sort | association of red blood cell distribution width coefficient of variation with cranial ultrasound abnormalities in neonatal hyperbilirubinemia a retrospective cross sectional study |
| topic | cranial red blood cell distribution width neonatal hyperbilirubinemia ultrasonography neuroimaging |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1488731/full |
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