Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty.

Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty.

Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence from the tsetse fly as obligatory vector, and independence from the need for functional mitochondrial DNA (kinetoplast or kDNA). In an effort to better understand the molecular causes and consequences o...

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Main Authors: Jason Carnes, Atashi Anupama, Oliver Balmer, Andrew Jackson, Michael Lewis, Rob Brown, Igor Cestari, Marc Desquesnes, Claire Gendrin, Christiane Hertz-Fowler, Hideo Imamura, Alasdair Ivens, Luděk Kořený, De-Hua Lai, Annette MacLeod, Suzanne M McDermott, Chris Merritt, Severine Monnerat, Wonjong Moon, Peter Myler, Isabelle Phan, Gowthaman Ramasamy, Dhileep Sivam, Zhao-Rong Lun, Julius Lukeš, Ken Stuart, Achim Schnaufer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0003404
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