Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index
Aim. To estimate the prevalence of ischemic stroke (IS) and the appointment of anticoagulant therapy in patients with atrial fibrillation (AF) depending on body mass index (BMI) as part of a retrospective analysis of big data from certain subjects of the Russian Federation using artificial intellige...
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«FIRMA «SILICEA» LLC
2023-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5359 |
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| author | M. A. Druzhilov T. Yu. Kuznetsova O. Yu. Druzhilova M. K. Tsarkova D. V. Gavrilov A. V. Gusev |
| author_facet | M. A. Druzhilov T. Yu. Kuznetsova O. Yu. Druzhilova M. K. Tsarkova D. V. Gavrilov A. V. Gusev |
| author_sort | M. A. Druzhilov |
| collection | DOAJ |
| description | Aim. To estimate the prevalence of ischemic stroke (IS) and the appointment of anticoagulant therapy in patients with atrial fibrillation (AF) depending on body mass index (BMI) as part of a retrospective analysis of big data from certain subjects of the Russian Federation using artificial intelligence technologies.Material and methods. The information was obtained from the Webiomed predictive analytics platform, which includes depersonalized data from electronic health records of patients in 6 Russian constituent, extracted using artificial intelligence technologies. Individuals with AF aged ≥18 years were selected with available data on BMI of 18,5-60,0 kg/m2 inclusive (n=56003; men, 41,0%; age, 67,4±14,5 years, CHA2DS2-VASc score, 3,4±1,8). The following BMI ranges were identified: 18,5-21,9 kg/m2, 22,0-24,9 kg/m2 (taken as a reference), 25,0-29,9 kg/m2, 30,0-34,9 kg/m2, 35,0-39,9 kg/m2 and 40,0-60,0 kg/m2. The indicators were analyzed in age ranges (≤64 years, 65-74 years, ≥75 years) separately among men and women.Results. Among men ≤64 years of age, patients with overweight and class 2 obesity were characterized by a significantly higher incidence of IS. Among women ≤64 years, a significantly higher frequency of IS was found in subgroups with overweight and class 1-3 obesity, while among women aged 65-74 years — in a subgroup with a BMI of 18,5-21,9 kg/m2. Patients aged ≥75 years showed an insignificant trend towards the maximum frequency of IS with a BMI of 18,5-21,9 kg/m2. A higher frequency of anticoagulant therapy prescription was found in subgroups with overweight and class 1-3 obesity; in most age and sex subgroups, the differences are significant. A significantly lower frequency of anticoagulant therapy prescription to persons ≥75 years of age with a BMI of 18,5-21,9 kg/m2 was noted.Conclusion. The study showed a significant BMI paradox in the context of the relationship between the frequency of IS and BMI value in patients with AF. A higher incidence of IS in persons ≤64 years of age with a BMI ≥25 kg/m2 compared with patients with normal weight may be an additional argument for establishing an indepen-dent prognostic role of obesity in the development of thromboembolic events in AF. |
| format | Article |
| id | doaj-art-d08ff2794c0544838ff2a07ab823b8a4 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-06-01 |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-d08ff2794c0544838ff2a07ab823b8a42025-08-20T03:43:40Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-06-0128510.15829/1560-4071-2023-53593769Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass indexM. A. Druzhilov0T. Yu. Kuznetsova1O. Yu. Druzhilova2M. K. Tsarkova3D. V. Gavrilov4A. V. Gusev5Petrozavodsk State UniversityPetrozavodsk State UniversityPetrozavodsk State UniversityPetrozavodsk State UniversityOOO K-SkyCentral Research Institute of Organization and InformatizationAim. To estimate the prevalence of ischemic stroke (IS) and the appointment of anticoagulant therapy in patients with atrial fibrillation (AF) depending on body mass index (BMI) as part of a retrospective analysis of big data from certain subjects of the Russian Federation using artificial intelligence technologies.Material and methods. The information was obtained from the Webiomed predictive analytics platform, which includes depersonalized data from electronic health records of patients in 6 Russian constituent, extracted using artificial intelligence technologies. Individuals with AF aged ≥18 years were selected with available data on BMI of 18,5-60,0 kg/m2 inclusive (n=56003; men, 41,0%; age, 67,4±14,5 years, CHA2DS2-VASc score, 3,4±1,8). The following BMI ranges were identified: 18,5-21,9 kg/m2, 22,0-24,9 kg/m2 (taken as a reference), 25,0-29,9 kg/m2, 30,0-34,9 kg/m2, 35,0-39,9 kg/m2 and 40,0-60,0 kg/m2. The indicators were analyzed in age ranges (≤64 years, 65-74 years, ≥75 years) separately among men and women.Results. Among men ≤64 years of age, patients with overweight and class 2 obesity were characterized by a significantly higher incidence of IS. Among women ≤64 years, a significantly higher frequency of IS was found in subgroups with overweight and class 1-3 obesity, while among women aged 65-74 years — in a subgroup with a BMI of 18,5-21,9 kg/m2. Patients aged ≥75 years showed an insignificant trend towards the maximum frequency of IS with a BMI of 18,5-21,9 kg/m2. A higher frequency of anticoagulant therapy prescription was found in subgroups with overweight and class 1-3 obesity; in most age and sex subgroups, the differences are significant. A significantly lower frequency of anticoagulant therapy prescription to persons ≥75 years of age with a BMI of 18,5-21,9 kg/m2 was noted.Conclusion. The study showed a significant BMI paradox in the context of the relationship between the frequency of IS and BMI value in patients with AF. A higher incidence of IS in persons ≤64 years of age with a BMI ≥25 kg/m2 compared with patients with normal weight may be an additional argument for establishing an indepen-dent prognostic role of obesity in the development of thromboembolic events in AF.https://russjcardiol.elpub.ru/jour/article/view/5359atrial fibrillationischemic strokeanticoagulant therapybody mass indexobesity |
| spellingShingle | M. A. Druzhilov T. Yu. Kuznetsova O. Yu. Druzhilova M. K. Tsarkova D. V. Gavrilov A. V. Gusev Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index Российский кардиологический журнал atrial fibrillation ischemic stroke anticoagulant therapy body mass index obesity |
| title | Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index |
| title_full | Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index |
| title_fullStr | Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index |
| title_full_unstemmed | Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index |
| title_short | Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index |
| title_sort | retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index |
| topic | atrial fibrillation ischemic stroke anticoagulant therapy body mass index obesity |
| url | https://russjcardiol.elpub.ru/jour/article/view/5359 |
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