Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern
Anaplastic large cell lymphoma with a small cell pattern is a rare T-cell lymphoma. This condition is more frequently seen in younger patients and should be considered when patients present with leucocytosis and constitutional symptoms. In this report, we describe our diagnostic work-up for one such...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/840253 |
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| _version_ | 1832552881088102400 |
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| author | Rowan L. Grigoropoulos Penny Wright Mars B. van t'Veer Mike A. Scott George A. Follows |
| author_facet | Rowan L. Grigoropoulos Penny Wright Mars B. van t'Veer Mike A. Scott George A. Follows |
| author_sort | Rowan L. Grigoropoulos |
| collection | DOAJ |
| description | Anaplastic large cell lymphoma with a small cell pattern is a rare T-cell lymphoma. This condition is more frequently seen in younger patients and should be considered when patients present with leucocytosis and constitutional symptoms. In this report, we describe our diagnostic work-up for one such case using blood, lymph node, and bone marrow aspirate samples, highlighting the variability of antigen expression seen in different sample types and methodologies. This case shows the importance of having a high index of suspicion and assessing CD30 and anaplastic lymphoma kinase expression in all suspected T-cell neoplasms even though this rare condition is not necessarily expected. |
| format | Article |
| id | doaj-art-d08f0fd8478647729bf67086a2e5466b |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d08f0fd8478647729bf67086a2e5466b2025-02-03T05:57:38ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/840253840253Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell PatternRowan L. Grigoropoulos0Penny Wright1Mars B. van t'Veer2Mike A. Scott3George A. Follows4Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UKDepartment of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UKDepartment of Haematology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UKDepartment of Haematology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UKDepartment of Haematology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB20QQ, UKAnaplastic large cell lymphoma with a small cell pattern is a rare T-cell lymphoma. This condition is more frequently seen in younger patients and should be considered when patients present with leucocytosis and constitutional symptoms. In this report, we describe our diagnostic work-up for one such case using blood, lymph node, and bone marrow aspirate samples, highlighting the variability of antigen expression seen in different sample types and methodologies. This case shows the importance of having a high index of suspicion and assessing CD30 and anaplastic lymphoma kinase expression in all suspected T-cell neoplasms even though this rare condition is not necessarily expected.http://dx.doi.org/10.1155/2013/840253 |
| spellingShingle | Rowan L. Grigoropoulos Penny Wright Mars B. van t'Veer Mike A. Scott George A. Follows Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern Case Reports in Hematology |
| title | Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern |
| title_full | Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern |
| title_fullStr | Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern |
| title_full_unstemmed | Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern |
| title_short | Pitfalls in the Diagnosis of Anaplastic Large Cell Lymphoma with a Small Cell Pattern |
| title_sort | pitfalls in the diagnosis of anaplastic large cell lymphoma with a small cell pattern |
| url | http://dx.doi.org/10.1155/2013/840253 |
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