Ulcerative colitis that developed during radiotherapy for prostate cancer, deteriorated rapidly and required emergency surgery
Abstract Background Although there are reports linking ulcerative colitis (UC) to prostate cancer (PC), those reports are of PC patients who were previously diagnosed with UC. There are no reports of the development of UC during radiotherapy. Here we describe the first case of a patient who develope...
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Japan Surgical Society
2020-10-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-020-01024-3 |
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| author | Keiji Matsuda Yuka Okada Yojiro Hashiguchi Kentaro Asako Kohei Ohno Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Tsuyoshi Ozawa Tamuro Hayama Keijiro Nozawa Takeo Fukagawa Yuko Sasajima |
| author_facet | Keiji Matsuda Yuka Okada Yojiro Hashiguchi Kentaro Asako Kohei Ohno Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Tsuyoshi Ozawa Tamuro Hayama Keijiro Nozawa Takeo Fukagawa Yuko Sasajima |
| author_sort | Keiji Matsuda |
| collection | DOAJ |
| description | Abstract Background Although there are reports linking ulcerative colitis (UC) to prostate cancer (PC), those reports are of PC patients who were previously diagnosed with UC. There are no reports of the development of UC during radiotherapy. Here we describe the first case of a patient who developed UC during radiotherapy for PC. The UC progressed rapidly and required emergency surgery. Case presentation A 61-year-old Japanese man underwent a prostate biopsy at another hospital due to a high prostate-specific antigen level and was diagnosed with PC. Goserelin and bicalutamide treatment was initiated in 2019, and intensity-modulated radiotherapy (total of 60 Gy/20 Fr) was administered in 2020. Diarrhea began during the radiotherapy and bleeding began post-radiotherapy. He was admitted to another hospital 14 days after the end of the radiotherapy, and colonoscopy revealed a deep ulcer in the colon, which led to the suspicion of UC. He was transferred to our hospital, and colonoscopy showed a widespread map-like ulcer, pseudopolyposis, and very easy bleeding in the colon. We diagnosed severe UC, and it worsened rapidly with uncontrollable bleeding, which we considered an indication for surgery. Emergency surgery (a total colectomy and ileostomy creation) was performed. The specimens confirmed an extensively spreading ulcer throughout the colon. The pathological report was UC in the active phase. The postoperative course was good. Conclusions When a patient exhibits diarrhea while undergoing radiotherapy for PC, clinicians should be aware of the possibility of UC in addition to radiation colitis, and colonoscopy should be considered. |
| format | Article |
| id | doaj-art-d08e68e3baf541c19fa720d4833faab3 |
| institution | DOAJ |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-d08e68e3baf541c19fa720d4833faab32025-08-20T02:51:35ZengJapan Surgical SocietySurgical Case Reports2198-77932020-10-01611710.1186/s40792-020-01024-3Ulcerative colitis that developed during radiotherapy for prostate cancer, deteriorated rapidly and required emergency surgeryKeiji Matsuda0Yuka Okada1Yojiro Hashiguchi2Kentaro Asako3Kohei Ohno4Mitsuo Tsukamoto5Yoshihisa Fukushima6Ryu Shimada7Tsuyoshi Ozawa8Tamuro Hayama9Keijiro Nozawa10Takeo Fukagawa11Yuko Sasajima12Department of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Pathology, Teikyo University School of MedicineAbstract Background Although there are reports linking ulcerative colitis (UC) to prostate cancer (PC), those reports are of PC patients who were previously diagnosed with UC. There are no reports of the development of UC during radiotherapy. Here we describe the first case of a patient who developed UC during radiotherapy for PC. The UC progressed rapidly and required emergency surgery. Case presentation A 61-year-old Japanese man underwent a prostate biopsy at another hospital due to a high prostate-specific antigen level and was diagnosed with PC. Goserelin and bicalutamide treatment was initiated in 2019, and intensity-modulated radiotherapy (total of 60 Gy/20 Fr) was administered in 2020. Diarrhea began during the radiotherapy and bleeding began post-radiotherapy. He was admitted to another hospital 14 days after the end of the radiotherapy, and colonoscopy revealed a deep ulcer in the colon, which led to the suspicion of UC. He was transferred to our hospital, and colonoscopy showed a widespread map-like ulcer, pseudopolyposis, and very easy bleeding in the colon. We diagnosed severe UC, and it worsened rapidly with uncontrollable bleeding, which we considered an indication for surgery. Emergency surgery (a total colectomy and ileostomy creation) was performed. The specimens confirmed an extensively spreading ulcer throughout the colon. The pathological report was UC in the active phase. The postoperative course was good. Conclusions When a patient exhibits diarrhea while undergoing radiotherapy for PC, clinicians should be aware of the possibility of UC in addition to radiation colitis, and colonoscopy should be considered.http://link.springer.com/article/10.1186/s40792-020-01024-3Ulcerative colitisProstate cancerRadiotherapyPSASurgery |
| spellingShingle | Keiji Matsuda Yuka Okada Yojiro Hashiguchi Kentaro Asako Kohei Ohno Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Tsuyoshi Ozawa Tamuro Hayama Keijiro Nozawa Takeo Fukagawa Yuko Sasajima Ulcerative colitis that developed during radiotherapy for prostate cancer, deteriorated rapidly and required emergency surgery Surgical Case Reports Ulcerative colitis Prostate cancer Radiotherapy PSA Surgery |
| title | Ulcerative colitis that developed during radiotherapy for prostate cancer, deteriorated rapidly and required emergency surgery |
| title_full | Ulcerative colitis that developed during radiotherapy for prostate cancer, deteriorated rapidly and required emergency surgery |
| title_fullStr | Ulcerative colitis that developed during radiotherapy for prostate cancer, deteriorated rapidly and required emergency surgery |
| title_full_unstemmed | Ulcerative colitis that developed during radiotherapy for prostate cancer, deteriorated rapidly and required emergency surgery |
| title_short | Ulcerative colitis that developed during radiotherapy for prostate cancer, deteriorated rapidly and required emergency surgery |
| title_sort | ulcerative colitis that developed during radiotherapy for prostate cancer deteriorated rapidly and required emergency surgery |
| topic | Ulcerative colitis Prostate cancer Radiotherapy PSA Surgery |
| url | http://link.springer.com/article/10.1186/s40792-020-01024-3 |
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