The On-Freezing Phenomenon: Cognitive and Behavioral Aspects
Freezing of gait is a warning sign of Parkinson's disease. One could distinguish off-freezing, which is associated with dopaminergic therapy and to its titration, and it is clinically related to wearing-off phenomenon. Differently, the on-freezing phenomenon seems to be related to a neural disr...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2011/746303 |
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| author | Rita Moretti Paola Torre Rodolfo M. Antonello Francesca Esposito Giuseppe Bellini |
| author_facet | Rita Moretti Paola Torre Rodolfo M. Antonello Francesca Esposito Giuseppe Bellini |
| author_sort | Rita Moretti |
| collection | DOAJ |
| description | Freezing of gait is a warning sign of Parkinson's disease. One could distinguish off-freezing, which is associated with dopaminergic therapy and to its titration, and it is clinically related to wearing-off phenomenon. Differently, the on-freezing phenomenon seems to be related to a neural disruption of the frontal-parietal-basal ganglia-pontine projections; clinically, it does not respond to therapy modifications or to different drug titration. In a group of patients with on-freezing, we have detected an alteration of focusing attention, an impairment of set-shifting, in addition to poor abstract reasoning and a reduction of planning. These aspects have been even more evident, when compared with the results obtained by a group of PD patients, without freezing. |
| format | Article |
| id | doaj-art-d08ae8e82c6248e28b02c8f0cfa9ef8e |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-d08ae8e82c6248e28b02c8f0cfa9ef8e2025-02-03T00:59:35ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/746303746303The On-Freezing Phenomenon: Cognitive and Behavioral AspectsRita Moretti0Paola Torre1Rodolfo M. Antonello2Francesca Esposito3Giuseppe Bellini4Medicina Clinica, Ambulatorio Complicanze Internistiche Cerebrali, Dipartimento Universitario Clinici di Scienze Mediche Tecnologiche e Traslazionali, Università degli Studi di Trieste, Ospedale di Cattinara, Strada Fiume 447, 34149 Trieste, ItalyMedicina Clinica, Ambulatorio Complicanze Internistiche Cerebrali, Dipartimento Universitario Clinici di Scienze Mediche Tecnologiche e Traslazionali, Università degli Studi di Trieste, Ospedale di Cattinara, Strada Fiume 447, 34149 Trieste, ItalyMedicina Clinica, Ambulatorio Complicanze Internistiche Cerebrali, Dipartimento Universitario Clinici di Scienze Mediche Tecnologiche e Traslazionali, Università degli Studi di Trieste, Ospedale di Cattinara, Strada Fiume 447, 34149 Trieste, ItalyMedicina Clinica, Ambulatorio Complicanze Internistiche Cerebrali, Dipartimento Universitario Clinici di Scienze Mediche Tecnologiche e Traslazionali, Università degli Studi di Trieste, Ospedale di Cattinara, Strada Fiume 447, 34149 Trieste, ItalyMedicina Clinica, Ambulatorio Complicanze Internistiche Cerebrali, Dipartimento Universitario Clinici di Scienze Mediche Tecnologiche e Traslazionali, Università degli Studi di Trieste, Ospedale di Cattinara, Strada Fiume 447, 34149 Trieste, ItalyFreezing of gait is a warning sign of Parkinson's disease. One could distinguish off-freezing, which is associated with dopaminergic therapy and to its titration, and it is clinically related to wearing-off phenomenon. Differently, the on-freezing phenomenon seems to be related to a neural disruption of the frontal-parietal-basal ganglia-pontine projections; clinically, it does not respond to therapy modifications or to different drug titration. In a group of patients with on-freezing, we have detected an alteration of focusing attention, an impairment of set-shifting, in addition to poor abstract reasoning and a reduction of planning. These aspects have been even more evident, when compared with the results obtained by a group of PD patients, without freezing.http://dx.doi.org/10.4061/2011/746303 |
| spellingShingle | Rita Moretti Paola Torre Rodolfo M. Antonello Francesca Esposito Giuseppe Bellini The On-Freezing Phenomenon: Cognitive and Behavioral Aspects Parkinson's Disease |
| title | The On-Freezing Phenomenon: Cognitive and Behavioral Aspects |
| title_full | The On-Freezing Phenomenon: Cognitive and Behavioral Aspects |
| title_fullStr | The On-Freezing Phenomenon: Cognitive and Behavioral Aspects |
| title_full_unstemmed | The On-Freezing Phenomenon: Cognitive and Behavioral Aspects |
| title_short | The On-Freezing Phenomenon: Cognitive and Behavioral Aspects |
| title_sort | on freezing phenomenon cognitive and behavioral aspects |
| url | http://dx.doi.org/10.4061/2011/746303 |
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