Exploration and mutagenesis of the germacrene A synthase from Solidago canadensis to enhance germacrene A production in E. coli

Exploration and mutagenesis of the germacrene A synthase from Solidago canadensis to enhance germacrene A production in E. coli

β-elemene is an effective anti-cancer component which has been widely used in clinic. However, it still relies on the extraction from the Chinese medicine plant Curcuma wenyujin, which seriously limits its application. Synthetic biology offers a promising approach to satisfy its supply. β-elemene is...

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Bibliographic Details
Main Authors: Jinyan Huo, Xiaohui Chu, Bo Hong, Ruo Lv, Xiaoyu Wang, Jianxu Li, Ge Jiang, Baomin Feng, Zongxia Yu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
β-elemene chassis
Germacrene A
Germacrene A synthase
Molecular docking
ScGAS mutagenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X25000328
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