In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation
Abstract The objective of this study is to fabricate and develop hydroxypropyl methylcellulose (HPMC) hydrogel (HG)-based composite bone cements with incorporation of hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and with/without polymethylmethacrylate (PMMA) for vertebroplasty. For animal...
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Springer
2025-01-01
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| Series: | Journal of Materials Science: Materials in Medicine |
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| Online Access: | https://doi.org/10.1007/s10856-024-06839-2 |
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| author | Mosharraf Hossain Tamima Sultana Ji Eun Moon Soobin Im Je Hoon Jeong |
| author_facet | Mosharraf Hossain Tamima Sultana Ji Eun Moon Soobin Im Je Hoon Jeong |
| author_sort | Mosharraf Hossain |
| collection | DOAJ |
| description | Abstract The objective of this study is to fabricate and develop hydroxypropyl methylcellulose (HPMC) hydrogel (HG)-based composite bone cements with incorporation of hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and with/without polymethylmethacrylate (PMMA) for vertebroplasty. For animal study, twenty female Wister rats (250–300 g, 12 weeks of age) were divided into four groups including a two non-ovariectomy (NOVX) groups and two ovariectomy (OVX)-induced osteoporosis groups. Two prepared biocomposites including HG/β-TCP/HA and HG/β-TCP/HA/PMMA were injected into the tibial defects of both OVX and NOVX rats for evaluating in vivo osteogenesis after 12 weeks. Micro-computed tomography and histological analysis using hematoxylin and eosin (H&E) and Masson's trichrome stains of the two composite cements implanted into the tibial defects of OVX and NOVX rats revealed enhanced bone regeneration potential. However, no statistically significant differences were noted among the groups based on new bone formation, demonstrating that the injected composite cements showed similar osteogenesis effects in both OVX and NOVX rats. These findings suggest that the newly developed composite bone cement composed of HG, β-TCP, HA and/or PMMA may be a promising and professional tool for treating osteoporotic and non-osteoporotic vertebral fractures. |
| format | Article |
| id | doaj-art-d0664e19376d45f38e929482d3c61525 |
| institution | Kabale University |
| issn | 1573-4838 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-d0664e19376d45f38e929482d3c615252025-02-02T12:06:31ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382025-01-0136111210.1007/s10856-024-06839-2In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigationMosharraf Hossain0Tamima Sultana1Ji Eun Moon2Soobin Im3Je Hoon Jeong4Department of Neurosurgery, College of Medicine, Soonchunhyang University, Bucheon HospitalDepartment of Neurosurgery, College of Medicine, Soonchunhyang University, Bucheon HospitalDepartment of Biostatistics, Clinical Trial Center, Soonchunhyang University, Bucheon HospitalDepartment of Neurosurgery, College of Medicine, Soonchunhyang University, Bucheon HospitalDepartment of Neurosurgery, College of Medicine, Soonchunhyang University, Bucheon HospitalAbstract The objective of this study is to fabricate and develop hydroxypropyl methylcellulose (HPMC) hydrogel (HG)-based composite bone cements with incorporation of hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and with/without polymethylmethacrylate (PMMA) for vertebroplasty. For animal study, twenty female Wister rats (250–300 g, 12 weeks of age) were divided into four groups including a two non-ovariectomy (NOVX) groups and two ovariectomy (OVX)-induced osteoporosis groups. Two prepared biocomposites including HG/β-TCP/HA and HG/β-TCP/HA/PMMA were injected into the tibial defects of both OVX and NOVX rats for evaluating in vivo osteogenesis after 12 weeks. Micro-computed tomography and histological analysis using hematoxylin and eosin (H&E) and Masson's trichrome stains of the two composite cements implanted into the tibial defects of OVX and NOVX rats revealed enhanced bone regeneration potential. However, no statistically significant differences were noted among the groups based on new bone formation, demonstrating that the injected composite cements showed similar osteogenesis effects in both OVX and NOVX rats. These findings suggest that the newly developed composite bone cement composed of HG, β-TCP, HA and/or PMMA may be a promising and professional tool for treating osteoporotic and non-osteoporotic vertebral fractures.https://doi.org/10.1007/s10856-024-06839-2Vertebral compression fractureosteoporosishydrogel-based bone cementin vivobone regeneration |
| spellingShingle | Mosharraf Hossain Tamima Sultana Ji Eun Moon Soobin Im Je Hoon Jeong In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation Journal of Materials Science: Materials in Medicine Vertebral compression fracture osteoporosis hydrogel-based bone cement in vivo bone regeneration |
| title | In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation |
| title_full | In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation |
| title_fullStr | In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation |
| title_full_unstemmed | In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation |
| title_short | In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation |
| title_sort | in vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel based composite bone cements in ovariectomized and ovary intact rats a preliminary investigation |
| topic | Vertebral compression fracture osteoporosis hydrogel-based bone cement in vivo bone regeneration |
| url | https://doi.org/10.1007/s10856-024-06839-2 |
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