Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma

Kaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS inclu...

Full description

Saved in:
Bibliographic Details
Main Authors: Owen Ngalamika, Sody Munsaka
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2020/8852221
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832550866211569664
author Owen Ngalamika
Sody Munsaka
author_facet Owen Ngalamika
Sody Munsaka
author_sort Owen Ngalamika
collection DOAJ
description Kaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of the immune system likely play distinct roles in promoting or inhibiting KS development. This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.
format Article
id doaj-art-d05c38ecf903436b8a6527fb962480c2
institution Kabale University
issn 2314-8861
2314-7156
language English
publishDate 2020-01-01
publisher Wiley
record_format Article
series Journal of Immunology Research
spelling doaj-art-d05c38ecf903436b8a6527fb962480c22025-02-03T06:05:38ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/88522218852221Cells of the Innate and Adaptive Immune Systems in Kaposi’s SarcomaOwen Ngalamika0Sody Munsaka1Dermatology and Venereology Division, University Teaching Hospital, University of Zambia School of Medicine, Lusaka, ZambiaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, ZambiaKaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of the immune system likely play distinct roles in promoting or inhibiting KS development. This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.http://dx.doi.org/10.1155/2020/8852221
spellingShingle Owen Ngalamika
Sody Munsaka
Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma
Journal of Immunology Research
title Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma
title_full Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma
title_fullStr Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma
title_full_unstemmed Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma
title_short Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma
title_sort cells of the innate and adaptive immune systems in kaposi s sarcoma
url http://dx.doi.org/10.1155/2020/8852221
work_keys_str_mv AT owenngalamika cellsoftheinnateandadaptiveimmunesystemsinkaposissarcoma
AT sodymunsaka cellsoftheinnateandadaptiveimmunesystemsinkaposissarcoma