Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma
Kaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS inclu...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8852221 |
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| _version_ | 1832550866211569664 |
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| author | Owen Ngalamika Sody Munsaka |
| author_facet | Owen Ngalamika Sody Munsaka |
| author_sort | Owen Ngalamika |
| collection | DOAJ |
| description | Kaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of the immune system likely play distinct roles in promoting or inhibiting KS development. This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS. |
| format | Article |
| id | doaj-art-d05c38ecf903436b8a6527fb962480c2 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d05c38ecf903436b8a6527fb962480c22025-02-03T06:05:38ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/88522218852221Cells of the Innate and Adaptive Immune Systems in Kaposi’s SarcomaOwen Ngalamika0Sody Munsaka1Dermatology and Venereology Division, University Teaching Hospital, University of Zambia School of Medicine, Lusaka, ZambiaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, ZambiaKaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS-defining malignancy. The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. It is therefore expected that different cell types of the immune system likely play distinct roles in promoting or inhibiting KS development. This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.http://dx.doi.org/10.1155/2020/8852221 |
| spellingShingle | Owen Ngalamika Sody Munsaka Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma Journal of Immunology Research |
| title | Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma |
| title_full | Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma |
| title_fullStr | Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma |
| title_full_unstemmed | Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma |
| title_short | Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma |
| title_sort | cells of the innate and adaptive immune systems in kaposi s sarcoma |
| url | http://dx.doi.org/10.1155/2020/8852221 |
| work_keys_str_mv | AT owenngalamika cellsoftheinnateandadaptiveimmunesystemsinkaposissarcoma AT sodymunsaka cellsoftheinnateandadaptiveimmunesystemsinkaposissarcoma |