Synapse Plasticity in Motor, Sensory, and Limbo-Prefrontal Cortex Areas as Measured by Degrading Axon Terminals in an Environment Model of Gerbils (Meriones unguiculatus)
Still little is known about naturally occurring synaptogenesis in the adult neocortex and related impacts of epigenetic influences. We therefore investigated (pre)synaptic plasticity in various cortices of adult rodents, visualized by secondary lysosome accumulations (LA) in remodeling axon terminal...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2009/281561 |
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| author | Janina Neufeld Gertraud Teuchert-Noodt Keren Grafen York Winter A. Veronica Witte |
| author_facet | Janina Neufeld Gertraud Teuchert-Noodt Keren Grafen York Winter A. Veronica Witte |
| author_sort | Janina Neufeld |
| collection | DOAJ |
| description | Still little is known about naturally occurring synaptogenesis in the adult neocortex and related impacts of epigenetic influences. We therefore investigated (pre)synaptic plasticity in various cortices of adult rodents, visualized by secondary lysosome accumulations (LA) in remodeling axon terminals. Twenty-two male gerbils from either enriched (ER) or impoverished rearing (IR) were used for quantification of silver-stained LA. ER-animals showed rather low LA densities in most primary fields, whereas barrel and secondary/associative cortices exhibited higher densities and layer-specific differences. In IR-animals, these differences were evened out or even inverted. Basic plastic capacities might be linked with remodeling of local intrinsic circuits in the context of cortical map adaptation in both IR- and ER-animals. Frequently described disturbances due to IR in multiple corticocortical and extracortical afferent systems, including the mesocortical dopamine projection, might have led to maladaptations in the plastic capacities of prefronto-limbic areas, as indicated by different LA densities in IR- compared with ER-animals. |
| format | Article |
| id | doaj-art-d05a010a1f6842058f9b43cc9da9436c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d05a010a1f6842058f9b43cc9da9436c2025-02-03T01:24:19ZengWileyNeural Plasticity2090-59041687-54432009-01-01200910.1155/2009/281561281561Synapse Plasticity in Motor, Sensory, and Limbo-Prefrontal Cortex Areas as Measured by Degrading Axon Terminals in an Environment Model of Gerbils (Meriones unguiculatus)Janina Neufeld0Gertraud Teuchert-Noodt1Keren Grafen2York Winter3A. Veronica Witte4Department of Biology and Neuroanatomy, Bielefeld University, 33501, Bielefeld, GermanyDepartment of Biology and Neuroanatomy, Bielefeld University, 33501, Bielefeld, GermanyDepartment of Biology and Neuroanatomy, Bielefeld University, 33501, Bielefeld, GermanyDepartment of Biology, Humboldt University, Berlin, GermanyDepartment of Neurology, Charité Universitätsmedizin, Berlin, GermanyStill little is known about naturally occurring synaptogenesis in the adult neocortex and related impacts of epigenetic influences. We therefore investigated (pre)synaptic plasticity in various cortices of adult rodents, visualized by secondary lysosome accumulations (LA) in remodeling axon terminals. Twenty-two male gerbils from either enriched (ER) or impoverished rearing (IR) were used for quantification of silver-stained LA. ER-animals showed rather low LA densities in most primary fields, whereas barrel and secondary/associative cortices exhibited higher densities and layer-specific differences. In IR-animals, these differences were evened out or even inverted. Basic plastic capacities might be linked with remodeling of local intrinsic circuits in the context of cortical map adaptation in both IR- and ER-animals. Frequently described disturbances due to IR in multiple corticocortical and extracortical afferent systems, including the mesocortical dopamine projection, might have led to maladaptations in the plastic capacities of prefronto-limbic areas, as indicated by different LA densities in IR- compared with ER-animals.http://dx.doi.org/10.1155/2009/281561 |
| spellingShingle | Janina Neufeld Gertraud Teuchert-Noodt Keren Grafen York Winter A. Veronica Witte Synapse Plasticity in Motor, Sensory, and Limbo-Prefrontal Cortex Areas as Measured by Degrading Axon Terminals in an Environment Model of Gerbils (Meriones unguiculatus) Neural Plasticity |
| title | Synapse Plasticity in Motor, Sensory, and Limbo-Prefrontal Cortex Areas as Measured by Degrading Axon Terminals in an Environment Model of Gerbils (Meriones unguiculatus) |
| title_full | Synapse Plasticity in Motor, Sensory, and Limbo-Prefrontal Cortex Areas as Measured by Degrading Axon Terminals in an Environment Model of Gerbils (Meriones unguiculatus) |
| title_fullStr | Synapse Plasticity in Motor, Sensory, and Limbo-Prefrontal Cortex Areas as Measured by Degrading Axon Terminals in an Environment Model of Gerbils (Meriones unguiculatus) |
| title_full_unstemmed | Synapse Plasticity in Motor, Sensory, and Limbo-Prefrontal Cortex Areas as Measured by Degrading Axon Terminals in an Environment Model of Gerbils (Meriones unguiculatus) |
| title_short | Synapse Plasticity in Motor, Sensory, and Limbo-Prefrontal Cortex Areas as Measured by Degrading Axon Terminals in an Environment Model of Gerbils (Meriones unguiculatus) |
| title_sort | synapse plasticity in motor sensory and limbo prefrontal cortex areas as measured by degrading axon terminals in an environment model of gerbils meriones unguiculatus |
| url | http://dx.doi.org/10.1155/2009/281561 |
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