MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3

MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3

Abstract Liver fibrosis is a common complication of T2DM(Type 2 diabetes mellitus). Appropriate intervention (exercise or drugs) in the early stage of liver fibrosis can slow down or even reverse liver fibrosis. MOTS-c (Mitochondrial open reading frame of the 12 S r RNA type-c ) has been described a...

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Bibliographic Details
Main Authors: Feilong Chen, Zhiyu Li, Tutu Wang, Yu Fu, Lei Lyu, Chengyuan Xing, Shunchang Li, Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
MOTS-c
T2DM
Aerobic exercise
Liver fibrosis
Keap1-Nrf2-Smad2/3 pathway
Online Access:https://doi.org/10.1038/s41598-025-03526-2
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