Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis

The current meta-analysis searched the literature connected to different tranquilizers used to treat elderly people and assessed it in terms of dose, types of outcomes and adverse effects, to determine a safe and acceptable tranquilizer and its optimal dose. A systematic literature review was undert...

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Main Authors: Li Jing, Cui Yulan, Li Honggeng, Hou Xiaoxuan, Zhao Fang, Zhao Qing, Zhao Junlan, Lin Pengchao
Format: Article
Language:English
Published: Sciendo 2023-03-01
Series:Acta Pharmaceutica
Subjects:
Online Access:https://doi.org/10.2478/acph-2023-0003
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author Li Jing
Li Jing
Cui Yulan
Li Honggeng
Hou Xiaoxuan
Zhao Fang
Zhao Qing
Zhao Junlan
Lin Pengchao
author_facet Li Jing
Li Jing
Cui Yulan
Li Honggeng
Hou Xiaoxuan
Zhao Fang
Zhao Qing
Zhao Junlan
Lin Pengchao
author_sort Li Jing
collection DOAJ
description The current meta-analysis searched the literature connected to different tranquilizers used to treat elderly people and assessed it in terms of dose, types of outcomes and adverse effects, to determine a safe and acceptable tranquilizer and its optimal dose. A systematic literature review was undertaken for randomized controlled trials, case-control, retrospective and prospective studies on the use of tranquilizers in elderly patients, using PubMed, Ebsco, SCOPUS and Web of Science. PICOS criteria were used to select studies, and pertinent event data was collected. This meta-analysis includes 16 randomized control trials spanning the years 2000 to 2022, using the data from 2224 patients. The trials that were included used various tranquilizers such as diazepam, alprazolam, temazepam and lorazepam, and indicated high treatment efficacy and low adverse effects. With a p-value of 0.853 for Egger’s test and 0.13 for Begg’s test, the current meta-analysis shows a minimal probability of publication bias. A recent meta-analysis supports the use of tranquilizers in older people to treat sleeplessness, epilepsy or anxiety, but only at modest doses, because large doses are harmful and produce numerous withdrawal symptoms.
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spelling doaj-art-d04f505e1d42421c86093f30e37480a12025-02-03T04:14:01ZengSciendoActa Pharmaceutica1846-95582023-03-01731435710.2478/acph-2023-0003Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysisLi Jing0Li Jing1Cui Yulan2Li Honggeng3Hou Xiaoxuan4Zhao Fang5Zhao Qing6Zhao Junlan7Lin Pengchao8Department of NursingDepartment of NursingDepartment of Hospital Infection ManagementDepartment of Integrated Traditional and Western MedicineDepartment of Integrated Traditional and Western MedicineDepartment of RespirationDepartment of Science and Education Eighth People ‘s Hospital of Hebei Province Shijiazhuang, Hebei Province, 050000, ChinaDepartment of NursingDepartment of Trauma and Orthopedics The Third Hospital of ShijiazhuangShijiazhuang, Hebei Province, 050000, ChinaThe current meta-analysis searched the literature connected to different tranquilizers used to treat elderly people and assessed it in terms of dose, types of outcomes and adverse effects, to determine a safe and acceptable tranquilizer and its optimal dose. A systematic literature review was undertaken for randomized controlled trials, case-control, retrospective and prospective studies on the use of tranquilizers in elderly patients, using PubMed, Ebsco, SCOPUS and Web of Science. PICOS criteria were used to select studies, and pertinent event data was collected. This meta-analysis includes 16 randomized control trials spanning the years 2000 to 2022, using the data from 2224 patients. The trials that were included used various tranquilizers such as diazepam, alprazolam, temazepam and lorazepam, and indicated high treatment efficacy and low adverse effects. With a p-value of 0.853 for Egger’s test and 0.13 for Begg’s test, the current meta-analysis shows a minimal probability of publication bias. A recent meta-analysis supports the use of tranquilizers in older people to treat sleeplessness, epilepsy or anxiety, but only at modest doses, because large doses are harmful and produce numerous withdrawal symptoms.https://doi.org/10.2478/acph-2023-0003tranquilizersbenzodiazepinesinsomniaepilepsyanxietyseniors
spellingShingle Li Jing
Li Jing
Cui Yulan
Li Honggeng
Hou Xiaoxuan
Zhao Fang
Zhao Qing
Zhao Junlan
Lin Pengchao
Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis
Acta Pharmaceutica
tranquilizers
benzodiazepines
insomnia
epilepsy
anxiety
seniors
title Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis
title_full Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis
title_fullStr Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis
title_full_unstemmed Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis
title_short Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis
title_sort effects of tranquilization therapy in elderly patients suffering from chronic non communicable diseases a meta analysis
topic tranquilizers
benzodiazepines
insomnia
epilepsy
anxiety
seniors
url https://doi.org/10.2478/acph-2023-0003
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