Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants
Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis of small and medium sized arteries. We report a case of a 49-year old woman who presented with PAN following exposure to silicone breast implants. Although the relationship between silicone implants and connective tissue diseases h...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2015/765170 |
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| _version_ | 1832553427269320704 |
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| author | Yamen Homsi John Andrew Carlson Samer Homsi |
| author_facet | Yamen Homsi John Andrew Carlson Samer Homsi |
| author_sort | Yamen Homsi |
| collection | DOAJ |
| description | Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis of small and medium sized arteries. We report a case of a 49-year old woman who presented with PAN following exposure to silicone breast implants. Although the relationship between silicone implants and connective tissue diseases has been investigated in the literature, no prior reports were found documenting PAN after silicone mammoplasty. While the pathogenesis of idiopathic PAN is not known yet, responsiveness to immunosuppressive therapy may suggest an immunologic mechanism. More robust research is needed to understand the connection between silicone breast implants and autoimmunity. |
| format | Article |
| id | doaj-art-d03d608499b6433c8b3cfe46d4494aec |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-d03d608499b6433c8b3cfe46d4494aec2025-02-03T05:54:03ZengWileyCase Reports in Rheumatology2090-68892090-68972015-01-01201510.1155/2015/765170765170Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast ImplantsYamen Homsi0John Andrew Carlson1Samer Homsi2Division of Rheumatology, Albany Medical Center, Albany, NY 12208, USADivision of Pathology, Albany Medical Center, Albany, NY 12208, USAPulmonary Department, Little Rock Diagnostic Clinic and Baptist Health Medical Center, Little Rock, AR 72205, USAPolyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis of small and medium sized arteries. We report a case of a 49-year old woman who presented with PAN following exposure to silicone breast implants. Although the relationship between silicone implants and connective tissue diseases has been investigated in the literature, no prior reports were found documenting PAN after silicone mammoplasty. While the pathogenesis of idiopathic PAN is not known yet, responsiveness to immunosuppressive therapy may suggest an immunologic mechanism. More robust research is needed to understand the connection between silicone breast implants and autoimmunity.http://dx.doi.org/10.1155/2015/765170 |
| spellingShingle | Yamen Homsi John Andrew Carlson Samer Homsi Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants Case Reports in Rheumatology |
| title | Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants |
| title_full | Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants |
| title_fullStr | Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants |
| title_full_unstemmed | Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants |
| title_short | Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants |
| title_sort | polyarteritis nodosa presenting as digital gangrene and breast lesion following exposure to silicone breast implants |
| url | http://dx.doi.org/10.1155/2015/765170 |
| work_keys_str_mv | AT yamenhomsi polyarteritisnodosapresentingasdigitalgangreneandbreastlesionfollowingexposuretosiliconebreastimplants AT johnandrewcarlson polyarteritisnodosapresentingasdigitalgangreneandbreastlesionfollowingexposuretosiliconebreastimplants AT samerhomsi polyarteritisnodosapresentingasdigitalgangreneandbreastlesionfollowingexposuretosiliconebreastimplants |