The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Viral infection is a common trigger for acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The aim of this study is to investigate the expression of cytokines in AECOPD. Patients with AECOPD requiring hospitalization were recruited. Meanwhile healthy volunteers of similar age tha...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8539294 |
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| author | Jingtong Zheng Yue Shi Lingxin Xiong Weijie Zhang Ying Li Peter G. Gibson Jodie L. Simpson Chao Zhang Junying Lu Jingying Sai Guoqiang Wang Fang Wang |
| author_facet | Jingtong Zheng Yue Shi Lingxin Xiong Weijie Zhang Ying Li Peter G. Gibson Jodie L. Simpson Chao Zhang Junying Lu Jingying Sai Guoqiang Wang Fang Wang |
| author_sort | Jingtong Zheng |
| collection | DOAJ |
| description | Viral infection is a common trigger for acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The aim of this study is to investigate the expression of cytokines in AECOPD. Patients with AECOPD requiring hospitalization were recruited. Meanwhile healthy volunteers of similar age that accepted routine check-ups and showed no clinical symptoms of inflammatory diseases were also recruited. Induced sputum and serum were collected. Induced sputum of participants was processed and tested for thirteen viruses and bacteria. Forty cytokines were assayed in serum using the Quantibody Human Inflammation Array 3 (Ray Biotech, Inc.). The most common virus detected in virus positive AECOPD (VP) was influenza A (16%). No virus was found in controls. Circulating levels of IL-6, TNF-α, and MCP-1 were elevated in VP and coinfection subjects (p<0.05), while the levels of 37 other cytokines showed no difference, compared with virus negative groups and controls (p>0.05). Additionally, VP patients were less likely to have received influenza vaccination. VP patients had a systemic inflammation response involving IL-6, TNF-α, and MCP-1 which may be due to virus-induced activation of macrophages. There are important opportunities for further investigating AECOPD mechanisms and for the development of better strategies in the management and prevention of virus-related AECOPD. |
| format | Article |
| id | doaj-art-d02335237eac460898c084aeb4301e16 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d02335237eac460898c084aeb4301e162025-02-03T01:11:45ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/85392948539294The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseJingtong Zheng0Yue Shi1Lingxin Xiong2Weijie Zhang3Ying Li4Peter G. Gibson5Jodie L. Simpson6Chao Zhang7Junying Lu8Jingying Sai9Guoqiang Wang10Fang Wang11Departments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, ChinaDepartments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, ChinaDepartments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, ChinaDepartment of Respiratory Disease, Jilin Provincial People’s Hospital, Changchun, ChinaDepartment of Disease Control and Prevention, Beijing Shunyi District Center, Beijing, ChinaDepartment of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, AustraliaDepartment of Respiratory and Sleep Medicine, University of Newcastle, New Lambton, NSW, AustraliaDepartments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, ChinaDepartments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, ChinaDepartments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, ChinaDepartments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, ChinaDepartments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, ChinaViral infection is a common trigger for acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The aim of this study is to investigate the expression of cytokines in AECOPD. Patients with AECOPD requiring hospitalization were recruited. Meanwhile healthy volunteers of similar age that accepted routine check-ups and showed no clinical symptoms of inflammatory diseases were also recruited. Induced sputum and serum were collected. Induced sputum of participants was processed and tested for thirteen viruses and bacteria. Forty cytokines were assayed in serum using the Quantibody Human Inflammation Array 3 (Ray Biotech, Inc.). The most common virus detected in virus positive AECOPD (VP) was influenza A (16%). No virus was found in controls. Circulating levels of IL-6, TNF-α, and MCP-1 were elevated in VP and coinfection subjects (p<0.05), while the levels of 37 other cytokines showed no difference, compared with virus negative groups and controls (p>0.05). Additionally, VP patients were less likely to have received influenza vaccination. VP patients had a systemic inflammation response involving IL-6, TNF-α, and MCP-1 which may be due to virus-induced activation of macrophages. There are important opportunities for further investigating AECOPD mechanisms and for the development of better strategies in the management and prevention of virus-related AECOPD.http://dx.doi.org/10.1155/2017/8539294 |
| spellingShingle | Jingtong Zheng Yue Shi Lingxin Xiong Weijie Zhang Ying Li Peter G. Gibson Jodie L. Simpson Chao Zhang Junying Lu Jingying Sai Guoqiang Wang Fang Wang The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease Journal of Immunology Research |
| title | The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
| title_full | The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
| title_fullStr | The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
| title_short | The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
| title_sort | expression of il 6 tnf α and mcp 1 in respiratory viral infection in acute exacerbations of chronic obstructive pulmonary disease |
| url | http://dx.doi.org/10.1155/2017/8539294 |
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