Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative review
Abstract CircRNA, which stands for circular RNA, consists of non-coding transcripts found in eukaryotic cells. These RNAs have the potential to modulate the cell cycle and several signaling pathways, affecting processes such as cell growth, proliferation, epithelial-mesenchymal transition, and apopt...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Surgical and Experimental Pathology |
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| Online Access: | https://doi.org/10.1186/s42047-025-00188-2 |
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| author | Anurag Singh Nidhi Anand Pallavi Srivastava |
| author_facet | Anurag Singh Nidhi Anand Pallavi Srivastava |
| author_sort | Anurag Singh |
| collection | DOAJ |
| description | Abstract CircRNA, which stands for circular RNA, consists of non-coding transcripts found in eukaryotic cells. These RNAs have the potential to modulate the cell cycle and several signaling pathways, affecting processes such as cell growth, proliferation, epithelial-mesenchymal transition, and apoptosis, thereby significantly contributing to cancer development. Gallbladder cancer, a biliary tract cancer, often presents at advanced stages and lacks early non-invasive biomarkers, underscoring the urgent need for their discovery. Although studies on non-coding RNAs have been carried out, their viability as biomarkers remains to be fully validated. Research has shown that circRNA is implicated in various cancers, including gallbladder cancer. Its increasingly recognized role in gallbladder malignancy could represent a promising RNA target for clinical diagnostics and treatment development. This review explores circRNA biogenesis and function, the signaling pathways it influences, and the latest research advances in gallbladder carcinoma. |
| format | Article |
| id | doaj-art-d01e3fd43e7c44d6b72e26c162b98d4d |
| institution | OA Journals |
| issn | 2520-8454 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Surgical and Experimental Pathology |
| spelling | doaj-art-d01e3fd43e7c44d6b72e26c162b98d4d2025-08-20T02:06:21ZengBMCSurgical and Experimental Pathology2520-84542025-06-018111310.1186/s42047-025-00188-2Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative reviewAnurag Singh0Nidhi Anand1Pallavi Srivastava2Department of Pathology, Sanjay Gandhi Institute of Medical SciencesDepartments of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti KhandDepartment of Pathology, Sanjay Gandhi Institute of Medical SciencesAbstract CircRNA, which stands for circular RNA, consists of non-coding transcripts found in eukaryotic cells. These RNAs have the potential to modulate the cell cycle and several signaling pathways, affecting processes such as cell growth, proliferation, epithelial-mesenchymal transition, and apoptosis, thereby significantly contributing to cancer development. Gallbladder cancer, a biliary tract cancer, often presents at advanced stages and lacks early non-invasive biomarkers, underscoring the urgent need for their discovery. Although studies on non-coding RNAs have been carried out, their viability as biomarkers remains to be fully validated. Research has shown that circRNA is implicated in various cancers, including gallbladder cancer. Its increasingly recognized role in gallbladder malignancy could represent a promising RNA target for clinical diagnostics and treatment development. This review explores circRNA biogenesis and function, the signaling pathways it influences, and the latest research advances in gallbladder carcinoma.https://doi.org/10.1186/s42047-025-00188-2Circular RNAGall bladder cancerCarcinogenesisSignalling pathwaysNon-coding RNA |
| spellingShingle | Anurag Singh Nidhi Anand Pallavi Srivastava Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative review Surgical and Experimental Pathology Circular RNA Gall bladder cancer Carcinogenesis Signalling pathways Non-coding RNA |
| title | Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative review |
| title_full | Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative review |
| title_fullStr | Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative review |
| title_full_unstemmed | Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative review |
| title_short | Biogenesis, function and role of circular RNA in Gall Bladder Carcinoma-A narrative review |
| title_sort | biogenesis function and role of circular rna in gall bladder carcinoma a narrative review |
| topic | Circular RNA Gall bladder cancer Carcinogenesis Signalling pathways Non-coding RNA |
| url | https://doi.org/10.1186/s42047-025-00188-2 |
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