Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression Omnibus
Naringenin (Nar) is a citrus fruit-derived phytoestrogen, a group of dietary compounds produced by a wide variety of plants. Due to structural similarity to 17‐β‐estradiol (E2), phytoestrogens can bind to estrogen receptors (ERs) to exert context-dependent estrogenic and/or anti-estrogenic effects....
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340925000319 |
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| author | Van T. Hoang Mackenzie L. Hawes Jack R. Elliott Steven Elliott Binghao Zou Stephen M. Boué Brian G. Rowan Bridgette M. Collins-Burow Jorge A. Belgodere Muralidharan Anbalagan Elizabeth C. Martin Matthew E. Burow |
| author_facet | Van T. Hoang Mackenzie L. Hawes Jack R. Elliott Steven Elliott Binghao Zou Stephen M. Boué Brian G. Rowan Bridgette M. Collins-Burow Jorge A. Belgodere Muralidharan Anbalagan Elizabeth C. Martin Matthew E. Burow |
| author_sort | Van T. Hoang |
| collection | DOAJ |
| description | Naringenin (Nar) is a citrus fruit-derived phytoestrogen, a group of dietary compounds produced by a wide variety of plants. Due to structural similarity to 17‐β‐estradiol (E2), phytoestrogens can bind to estrogen receptors (ERs) to exert context-dependent estrogenic and/or anti-estrogenic effects. As such, there are potential health benefits and risks associated with phytoestrogen exposure. To investigate the effects of Nar in breast cancer, based on its activity as a phytoestrogen, we treated MCF-7 ER-positive (ER+) breast cancer cells with Nar (10 µM) and examined transcriptomic changes in MCF-7 cells induced by Nar treatment. Pathway analysis included in our dataset shows upregulation of genes associated with estrogen signaling and epithelial-to-mesenchymal transition in breast cancer cells treated with naringenin. |
| format | Article |
| id | doaj-art-d01bfb7a9d9b4581b8baab41710f87b0 |
| institution | Kabale University |
| issn | 2352-3409 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj-art-d01bfb7a9d9b4581b8baab41710f87b02025-01-26T05:04:04ZengElsevierData in Brief2352-34092025-04-0159111299Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression OmnibusVan T. Hoang0Mackenzie L. Hawes1Jack R. Elliott2Steven Elliott3Binghao Zou4Stephen M. Boué5Brian G. Rowan6Bridgette M. Collins-Burow7Jorge A. Belgodere8Muralidharan Anbalagan9Elizabeth C. Martin10Matthew E. Burow11Tulane Department of Medicine, Section of Hematology & Medical Oncology, Tulane University Health Science Center, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University, New Orleans, LA 70112, USA; Corresponding authors.Tulane Department of Medicine, Section of Hematology & Medical Oncology, Tulane University Health Science Center, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University, New Orleans, LA 70112, USATulane Department of Medicine, Section of Hematology & Medical Oncology, Tulane University Health Science Center, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University, New Orleans, LA 70112, USATulane Department of Medicine, Section of Hematology & Medical Oncology, Tulane University Health Science Center, New Orleans, LA 70112, USADepartment of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USAU. S. Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, LA 70179, USADepartment of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USATulane Department of Medicine, Section of Hematology & Medical Oncology, Tulane University Health Science Center, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University, New Orleans, LA 70112, USATulane Department of Medicine, Section of Hematology & Medical Oncology, Tulane University Health Science Center, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University, New Orleans, LA 70112, USA; Department of Biological and Agricultural Engineering, Louisiana State University and Agricultural Center, Baton Rouge, LA 70803, USADepartment of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USATulane Department of Medicine, Section of Hematology & Medical Oncology, Tulane University Health Science Center, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University, New Orleans, LA 70112, USATulane Department of Medicine, Section of Hematology & Medical Oncology, Tulane University Health Science Center, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University, New Orleans, LA 70112, USA; Corresponding authors.Naringenin (Nar) is a citrus fruit-derived phytoestrogen, a group of dietary compounds produced by a wide variety of plants. Due to structural similarity to 17‐β‐estradiol (E2), phytoestrogens can bind to estrogen receptors (ERs) to exert context-dependent estrogenic and/or anti-estrogenic effects. As such, there are potential health benefits and risks associated with phytoestrogen exposure. To investigate the effects of Nar in breast cancer, based on its activity as a phytoestrogen, we treated MCF-7 ER-positive (ER+) breast cancer cells with Nar (10 µM) and examined transcriptomic changes in MCF-7 cells induced by Nar treatment. Pathway analysis included in our dataset shows upregulation of genes associated with estrogen signaling and epithelial-to-mesenchymal transition in breast cancer cells treated with naringenin.http://www.sciencedirect.com/science/article/pii/S2352340925000319PhytoestrogenRNA-seqEstrogen responseEpithelial to mesenchymal transitionPlant-derived compoundsDietary compounds |
| spellingShingle | Van T. Hoang Mackenzie L. Hawes Jack R. Elliott Steven Elliott Binghao Zou Stephen M. Boué Brian G. Rowan Bridgette M. Collins-Burow Jorge A. Belgodere Muralidharan Anbalagan Elizabeth C. Martin Matthew E. Burow Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression Omnibus Data in Brief Phytoestrogen RNA-seq Estrogen response Epithelial to mesenchymal transition Plant-derived compounds Dietary compounds |
| title | Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression Omnibus |
| title_full | Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression Omnibus |
| title_fullStr | Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression Omnibus |
| title_full_unstemmed | Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression Omnibus |
| title_short | Dataset of transcriptomic changes induced by naringenin treatment in MCF-7 breast cancer cellsGene Expression Omnibus |
| title_sort | dataset of transcriptomic changes induced by naringenin treatment in mcf 7 breast cancer cellsgene expression omnibus |
| topic | Phytoestrogen RNA-seq Estrogen response Epithelial to mesenchymal transition Plant-derived compounds Dietary compounds |
| url | http://www.sciencedirect.com/science/article/pii/S2352340925000319 |
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