Preclinical Evaluation of Selene-Ethylenelacticamides in Tuberculosis: Effects Against Active, Dormant, and Resistant <i>Mycobacterium Tuberculosis</i> and In Vitro Toxicity Investigation

Preclinical Evaluation of Selene-Ethylenelacticamides in Tuberculosis: Effects Against Active, Dormant, and Resistant <i>Mycobacterium Tuberculosis</i> and In Vitro Toxicity Investigation

Selene-ethylenelacticamide derivatives have been suggested as promising scaffolds with leishmanicidal activity. In this work, we demonstrated, for the first time, the effectiveness of selene-ethylenelacticamide derivatives against mycobacteria. Firstly, selene-ethylenelacticamides inhibited the grow...

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Main Authors: Natália Ferreira de Sousa, Maria Eugênia G. de Freitas, Maria Gabriella S. Sidrônio, Helivaldo Diógenes Souza, Alexia Czeczot, Marcia Perelló, Gabriela Fehn Fiss, Luciana Scotti, Demétrius A. M. de Araújo, José Maria Barbosa Filho, Cristiano V. Bizarro, Pablo Machado, Luiz Augusto Basso, Francisco Jaime B. Mendonça-Junior, Petrônio F. de Athayde Filho, Marcus T. Scotti, Valnês S. Rodrigues-Junior
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Microorganisms
Subjects:
tuberculosis
drug development
selene-ethylenelacticamides
resistance
dormancy
toxicity
Online Access:https://www.mdpi.com/2076-2607/13/2/396
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