Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study
Objectives: Although curative resection for synchronous peritoneal carcinomatosis has been reported to improve prognosis, cases with positive intraoperative lavage cytology have not been reported. In this study, we investigated the prognostic value of potentially curative resection based on colorect...
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| Format: | Article |
| Language: | English |
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The Japan Society of Coloproctology
2025-01-01
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| Series: | Journal of the Anus, Rectum and Colon |
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| Online Access: | https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-079/_pdf/-char/en |
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| author | Kentaro Sato Shimpei Matsui Tomohiro Chiba Tatsuki Noguchi Takashi Sakamoto Toshiki Mukai Tomohiro Yamaguchi Takashi Akiyoshi Yosuke Fukunaga |
| author_facet | Kentaro Sato Shimpei Matsui Tomohiro Chiba Tatsuki Noguchi Takashi Sakamoto Toshiki Mukai Tomohiro Yamaguchi Takashi Akiyoshi Yosuke Fukunaga |
| author_sort | Kentaro Sato |
| collection | DOAJ |
| description | Objectives: Although curative resection for synchronous peritoneal carcinomatosis has been reported to improve prognosis, cases with positive intraoperative lavage cytology have not been reported. In this study, we investigated the prognostic value of potentially curative resection based on colorectal cancer and lavage cytology positivity in patients with synchronous peritoneal carcinomatosis.
Methods: We retrospectively evaluated 72 patients who underwent intraoperative lavage cytology and one-stage potentially curative resection of primary and metastatic lesions (lavage cytology-positive, n = 21; lavage cytology-negative, n = 51) between July 2004 and December 2019. We compared the 5-year overall survival and 3-year recurrence rates between the lavage cytology-positive and lavage cytology-negative groups.
Results: No significant differences were observed in the 5-year overall survival (48.2% vs. 45.5%, P = 0.924) or 3-year recurrence rates (74.5% vs. 62%, P = 0.143) between the two groups. Univariate analysis for 3-year recurrence revealed that lavage cytology-positive status was not an explanatory variable (hazard ratio: 1.552, 95% confidence interval: 0.83-2.902, P = 0.169). Multivariate analysis identified colon cancer as an independent risk factor of recurrence.
Conclusions: In resectable cases, the resection of synchronous peritoneal carcinomatosis from colorectal cancer can be considered even if intraoperative lavage cytology is positive. |
| format | Article |
| id | doaj-art-d0129e4a4af04354b289c669010f166b |
| institution | Kabale University |
| issn | 2432-3853 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Japan Society of Coloproctology |
| record_format | Article |
| series | Journal of the Anus, Rectum and Colon |
| spelling | doaj-art-d0129e4a4af04354b289c669010f166b2025-01-27T10:02:40ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532025-01-0191526010.23922/jarc.2024-0792024-079Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational StudyKentaro Sato0Shimpei Matsui1Tomohiro Chiba2Tatsuki Noguchi3Takashi Sakamoto4Toshiki Mukai5Tomohiro Yamaguchi6Takashi Akiyoshi7Yosuke Fukunaga8Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchDepartment of Cytology, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer ResearchObjectives: Although curative resection for synchronous peritoneal carcinomatosis has been reported to improve prognosis, cases with positive intraoperative lavage cytology have not been reported. In this study, we investigated the prognostic value of potentially curative resection based on colorectal cancer and lavage cytology positivity in patients with synchronous peritoneal carcinomatosis. Methods: We retrospectively evaluated 72 patients who underwent intraoperative lavage cytology and one-stage potentially curative resection of primary and metastatic lesions (lavage cytology-positive, n = 21; lavage cytology-negative, n = 51) between July 2004 and December 2019. We compared the 5-year overall survival and 3-year recurrence rates between the lavage cytology-positive and lavage cytology-negative groups. Results: No significant differences were observed in the 5-year overall survival (48.2% vs. 45.5%, P = 0.924) or 3-year recurrence rates (74.5% vs. 62%, P = 0.143) between the two groups. Univariate analysis for 3-year recurrence revealed that lavage cytology-positive status was not an explanatory variable (hazard ratio: 1.552, 95% confidence interval: 0.83-2.902, P = 0.169). Multivariate analysis identified colon cancer as an independent risk factor of recurrence. Conclusions: In resectable cases, the resection of synchronous peritoneal carcinomatosis from colorectal cancer can be considered even if intraoperative lavage cytology is positive.https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-079/_pdf/-char/enperitoneal cytologylavage cytologycolorectal cancerprognosis |
| spellingShingle | Kentaro Sato Shimpei Matsui Tomohiro Chiba Tatsuki Noguchi Takashi Sakamoto Toshiki Mukai Tomohiro Yamaguchi Takashi Akiyoshi Yosuke Fukunaga Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study Journal of the Anus, Rectum and Colon peritoneal cytology lavage cytology colorectal cancer prognosis |
| title | Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study |
| title_full | Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study |
| title_fullStr | Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study |
| title_full_unstemmed | Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study |
| title_short | Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study |
| title_sort | prognostic impact of potentially curative resection for synchronous peritoneal carcinomatosis with lavage cytology positivity in colorectal cancer a retrospective observational study |
| topic | peritoneal cytology lavage cytology colorectal cancer prognosis |
| url | https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-079/_pdf/-char/en |
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