Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy

Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy

Background: A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 polarization among tumor-infiltrating macrophages. P2X7 receptor has been previ...

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Bibliographic Details
Main Authors: Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Immunobiology
Subjects:
Ovarian cancer
M2 macrophage
Chimeric antigen receptor T
P2X7 receptor
STAT6
Online Access:http://www.sciencedirect.com/science/article/pii/S0171298524000810
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