Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population
(1) Background: This study is designed to establish thyroid-stimulating hormone (TSH) reference intervals tailored to different neonatal age groups and Indonesian local populations. (2) Methods: Dried blood spot neonatal TSH values, from 1 January 2022 to 31 December 2023, were used to establish the...
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MDPI AG
2025-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/12/1/104 |
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| author | Hery Priyanto Fauqa Arinil Aulia Hartono Kahar Muhammad Faizi Ferdy Royland Marpaung Aryati Aryati |
| author_facet | Hery Priyanto Fauqa Arinil Aulia Hartono Kahar Muhammad Faizi Ferdy Royland Marpaung Aryati Aryati |
| author_sort | Hery Priyanto |
| collection | DOAJ |
| description | (1) Background: This study is designed to establish thyroid-stimulating hormone (TSH) reference intervals tailored to different neonatal age groups and Indonesian local populations. (2) Methods: Dried blood spot neonatal TSH values, from 1 January 2022 to 31 December 2023, were used to establish the neonatal TSH reference intervals partitioned by sex, gestational age, and ethnic group at different neonatal ages. (3) Results: A significant difference in the reference intervals value was observed in sex, gestational ages, and parental ethnicity groups in different neonatal age subgroups (<i>p</i> < 0.05). Male reference intervals were significantly higher than those of females at all neonatal ages. Late and post-term gestational age categories reference intervals were higher than early and full-term. Among the ethnic groups, Madurese had a higher upper limit TSH reference interval. (4) Conclusions: Our neonatal TSH reference intervals were needed to provide a reference adapted to the local population of Indonesia. |
| format | Article |
| id | doaj-art-d00f22e159344eca882e79d1481d2aff |
| institution | Kabale University |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-d00f22e159344eca882e79d1481d2aff2025-01-24T13:27:19ZengMDPI AGChildren2227-90672025-01-0112110410.3390/children12010104Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics PopulationHery Priyanto0Fauqa Arinil Aulia1Hartono Kahar2Muhammad Faizi3Ferdy Royland Marpaung4Aryati Aryati5Clinical Pathology Sub-Specialization Program, Department of Clinical Pathology Dr. Soetomo Academic Hospital, Faculty of Medicine Universitas Airlangga, Surabaya 60132, IndonesiaDepartment of Clinical Pathology Dr. Soetomo Academic Hospital, Faculty of Medicine Universitas Airlangga, Surabaya 60132, IndonesiaDepartment of Clinical Pathology Dr. Soetomo Academic Hospital, Faculty of Medicine Universitas Airlangga, Surabaya 60132, IndonesiaDepartment of Child Health, Dr. Soetomo Academic Hospital, Faculty of Medicine Universitas Airlangga, Surabaya 60132, IndonesiaDepartment of Clinical Pathology Dr. Soetomo Academic Hospital, Faculty of Medicine Universitas Airlangga, Surabaya 60132, IndonesiaDepartment of Clinical Pathology Dr. Soetomo Academic Hospital, Faculty of Medicine Universitas Airlangga, Surabaya 60132, Indonesia(1) Background: This study is designed to establish thyroid-stimulating hormone (TSH) reference intervals tailored to different neonatal age groups and Indonesian local populations. (2) Methods: Dried blood spot neonatal TSH values, from 1 January 2022 to 31 December 2023, were used to establish the neonatal TSH reference intervals partitioned by sex, gestational age, and ethnic group at different neonatal ages. (3) Results: A significant difference in the reference intervals value was observed in sex, gestational ages, and parental ethnicity groups in different neonatal age subgroups (<i>p</i> < 0.05). Male reference intervals were significantly higher than those of females at all neonatal ages. Late and post-term gestational age categories reference intervals were higher than early and full-term. Among the ethnic groups, Madurese had a higher upper limit TSH reference interval. (4) Conclusions: Our neonatal TSH reference intervals were needed to provide a reference adapted to the local population of Indonesia.https://www.mdpi.com/2227-9067/12/1/104reference intervalsthyroid stimulating hormonedry blood spotchild health |
| spellingShingle | Hery Priyanto Fauqa Arinil Aulia Hartono Kahar Muhammad Faizi Ferdy Royland Marpaung Aryati Aryati Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population Children reference intervals thyroid stimulating hormone dry blood spot child health |
| title | Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population |
| title_full | Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population |
| title_fullStr | Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population |
| title_full_unstemmed | Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population |
| title_short | Neonatal Thyroid-Stimulating Hormone Reference Intervals in Multi-Ethnics Population |
| title_sort | neonatal thyroid stimulating hormone reference intervals in multi ethnics population |
| topic | reference intervals thyroid stimulating hormone dry blood spot child health |
| url | https://www.mdpi.com/2227-9067/12/1/104 |
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