Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4

Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4

Abstract Neuropathic pain is a chronic condition with limited effective treatments, closely associated with astrocytes and their role in central sensitization. Apolipoprotein E (ApoE), predominantly expressed in astrocytes in central nervous system, exists in three ApoE isoforms (ApoE2, ApoE3, and A...

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Bibliographic Details
Main Authors: Kaiming Yu, Xiongyao Zhou, Baolong Li, Jialu Sun, Tuo Yang, Weizhen Li, Ningning Wang, Xiaosong Gu, Shusen Cui, Rangjuan Cao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:The Journal of Headache and Pain
Subjects:
ApoE4
Neuropathic pain
Astrocyte
Spermidine
NOS2
Online Access:https://doi.org/10.1186/s10194-025-02054-8
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