Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles
Ang-(1–7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2. In the cardiovascular system, Ang-(1–7) has been shown to produce effects that are opposite to those of Ang II. These include smooth muscle relaxation and cardioprotection. While the roles...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/121740 |
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| author | Marcio Augusto Fressatto de Godoy Larissa Pernomian Ana Maria de Oliveira Satish Rattan |
| author_facet | Marcio Augusto Fressatto de Godoy Larissa Pernomian Ana Maria de Oliveira Satish Rattan |
| author_sort | Marcio Augusto Fressatto de Godoy |
| collection | DOAJ |
| description | Ang-(1–7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2. In the cardiovascular system, Ang-(1–7) has been shown to produce effects that are opposite to those of Ang II. These include smooth muscle relaxation and cardioprotection. While the roles of Ang-(1–7) in other systems are currently topic of intense research, functional data suggest a relaxation action in gastrointestinal smooth muscles in a way that corroborates the results obtained from vascular tissues. However, more studies are necessary to determine a relevant role for Ang-(1–7) in the gastrointestinal system. The Ang-(1–7) actions are mediated by a distinct, functional, Ang-(1–7) receptor: the Mas receptor as shown by diverse studies involving site-specific binding techniques, selective antagonists, and targeted gene deletion. This paper provides an overview of the functional role and the molecular pathways involved in the biosynthesis and activity of Ang-(1–7) in diverse systems. |
| format | Article |
| id | doaj-art-cffe5535e3bc445a86b5e73227ceac45 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-cffe5535e3bc445a86b5e73227ceac452025-02-03T06:07:57ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/121740121740Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth MusclesMarcio Augusto Fressatto de Godoy0Larissa Pernomian1Ana Maria de Oliveira2Satish Rattan3Division of Gastroenterology & Hepatology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USALaboratory of Pharmacology, Department of Pharmacology, Faculty of Medicine from Ribeirão Preto, University of São Paulo (USP), Avenida do Café s/n, 14040-903 Ribeirão Preto, SP, BrazilLaboratory of Pharmacology, Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences from Ribeirão Preto, University of São Paulo (USP), Avenida do Café s/n, 14040-903 Ribeirão Preto, SP, BrazilDivision of Gastroenterology & Hepatology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USAAng-(1–7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2. In the cardiovascular system, Ang-(1–7) has been shown to produce effects that are opposite to those of Ang II. These include smooth muscle relaxation and cardioprotection. While the roles of Ang-(1–7) in other systems are currently topic of intense research, functional data suggest a relaxation action in gastrointestinal smooth muscles in a way that corroborates the results obtained from vascular tissues. However, more studies are necessary to determine a relevant role for Ang-(1–7) in the gastrointestinal system. The Ang-(1–7) actions are mediated by a distinct, functional, Ang-(1–7) receptor: the Mas receptor as shown by diverse studies involving site-specific binding techniques, selective antagonists, and targeted gene deletion. This paper provides an overview of the functional role and the molecular pathways involved in the biosynthesis and activity of Ang-(1–7) in diverse systems.http://dx.doi.org/10.1155/2012/121740 |
| spellingShingle | Marcio Augusto Fressatto de Godoy Larissa Pernomian Ana Maria de Oliveira Satish Rattan Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles International Journal of Hypertension |
| title | Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles |
| title_full | Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles |
| title_fullStr | Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles |
| title_full_unstemmed | Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles |
| title_short | Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles |
| title_sort | biosynthetic pathways and the role of the mas receptor in the effects of angiotensin 1 7 in smooth muscles |
| url | http://dx.doi.org/10.1155/2012/121740 |
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