Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms
Pediatric traumatic brain injury (TBI) and autism spectrum disorder (ASD) are two serious conditions that affect youth. Recent data, both preclinical and clinical, show that pediatric TBI and ASD share not only similar symptoms but also some of the same biologic mechanisms that cause these symptoms....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2016/8781725 |
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| _version_ | 1832560834038988800 |
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| author | Rahul Singh Ryan C. Turner Linda Nguyen Kartik Motwani Michelle Swatek Brandon P. Lucke-Wold |
| author_facet | Rahul Singh Ryan C. Turner Linda Nguyen Kartik Motwani Michelle Swatek Brandon P. Lucke-Wold |
| author_sort | Rahul Singh |
| collection | DOAJ |
| description | Pediatric traumatic brain injury (TBI) and autism spectrum disorder (ASD) are two serious conditions that affect youth. Recent data, both preclinical and clinical, show that pediatric TBI and ASD share not only similar symptoms but also some of the same biologic mechanisms that cause these symptoms. Prominent symptoms for both disorders include gastrointestinal problems, learning difficulties, seizures, and sensory processing disruption. In this review, we highlight some of these shared mechanisms in order to discuss potential treatment options that might be applied for each condition. We discuss potential therapeutic and pharmacologic options as well as potential novel drug targets. Furthermore, we highlight advances in understanding of brain circuitry that is being propelled by improved imaging modalities. Going forward, advanced imaging will help in diagnosis and treatment planning strategies for pediatric patients. Lessons from each field can be applied to design better and more rigorous trials that can be used to improve guidelines for pediatric patients suffering from TBI or ASD. |
| format | Article |
| id | doaj-art-cffa55346c2b4bbb86d9545163f90a99 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-cffa55346c2b4bbb86d9545163f90a992025-02-03T01:26:41ZengWileyBehavioural Neurology0953-41801875-85842016-01-01201610.1155/2016/87817258781725Pediatric Traumatic Brain Injury and Autism: Elucidating Shared MechanismsRahul Singh0Ryan C. Turner1Linda Nguyen2Kartik Motwani3Michelle Swatek4Brandon P. Lucke-Wold5Department of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV 26505, USADepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV 26505, USADepartment of Basic Pharmaceutical Sciences, West Virginia University School of Medicine, Morgantown, WV 26505, USADepartment of Medical Sciences, University of Florida School of Medicine, Gainesville, FL 32611, USADepartment of Psychology, North Carolina State University, Raleigh, NC 27695, USADepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV 26505, USAPediatric traumatic brain injury (TBI) and autism spectrum disorder (ASD) are two serious conditions that affect youth. Recent data, both preclinical and clinical, show that pediatric TBI and ASD share not only similar symptoms but also some of the same biologic mechanisms that cause these symptoms. Prominent symptoms for both disorders include gastrointestinal problems, learning difficulties, seizures, and sensory processing disruption. In this review, we highlight some of these shared mechanisms in order to discuss potential treatment options that might be applied for each condition. We discuss potential therapeutic and pharmacologic options as well as potential novel drug targets. Furthermore, we highlight advances in understanding of brain circuitry that is being propelled by improved imaging modalities. Going forward, advanced imaging will help in diagnosis and treatment planning strategies for pediatric patients. Lessons from each field can be applied to design better and more rigorous trials that can be used to improve guidelines for pediatric patients suffering from TBI or ASD.http://dx.doi.org/10.1155/2016/8781725 |
| spellingShingle | Rahul Singh Ryan C. Turner Linda Nguyen Kartik Motwani Michelle Swatek Brandon P. Lucke-Wold Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms Behavioural Neurology |
| title | Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms |
| title_full | Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms |
| title_fullStr | Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms |
| title_full_unstemmed | Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms |
| title_short | Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms |
| title_sort | pediatric traumatic brain injury and autism elucidating shared mechanisms |
| url | http://dx.doi.org/10.1155/2016/8781725 |
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