Improving effects of melatonin on memory and synaptic potentiation in a mouse model of Alzheimer’s-like disease: the involvement of glutamate homeostasis and mGluRs receptors

Improving effects of melatonin on memory and synaptic potentiation in a mouse model of Alzheimer’s-like disease: the involvement of glutamate homeostasis and mGluRs receptors

Abstract Background Alzheimer's disease (AD) is characterized by progressive cognitive decline and synaptic dysfunction, largely driven by amyloid plaques and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. These pathological hallmarks disrupt glutamate signaling, which is e...

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Bibliographic Details
Main Authors: Narjes Khatoun Shabani Sadr, Fatemeh Bakhtiarzadeh, Koorosh Shahpasand, Javad Mirnajafi-Zadeh, Mehrdad Behmanesh
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Behavioral and Brain Functions
Subjects:
Alzheimer's disease
Memory
Synaptic plasticity
Glutamate signaling
Melatonin
Metabotropic glutamate receptors
Online Access:https://doi.org/10.1186/s12993-025-00271-4
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