Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis
Abstract Introduction In this study, we assessed whether the ratio of glucose management index (GMI) to glycated albumin (GA) was linked to microvascular complications in patients with type 2 diabetes mellitus (T2DM) who also possessed a shortened erythrocyte lifespan. Methods This study encompassed...
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BMC
2025-01-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01591-1 |
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| author | Yunqi Wu Binshan Zhang Xin Ma Pei Yu Saijun Zhou Xinli Wang |
| author_facet | Yunqi Wu Binshan Zhang Xin Ma Pei Yu Saijun Zhou Xinli Wang |
| author_sort | Yunqi Wu |
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| description | Abstract Introduction In this study, we assessed whether the ratio of glucose management index (GMI) to glycated albumin (GA) was linked to microvascular complications in patients with type 2 diabetes mellitus (T2DM) who also possessed a shortened erythrocyte lifespan. Methods This study encompassed individuals from the Tianjin Diabetic Retinopathy Screening Cohort who completed continuous glucose monitoring and had an erythrocyte lifespan of under 90 days. Differences in GMI/GA were compared between the T2DM patients with or without microvascular complications, including diabetic kidney disease (DKD) and diabetic retinopathy (DR). The relationship between GMI/GA and microvascular complications (DKD and/or DR) was assessed by dividing GMI/GA into three groups based on tertiles. Results Our study comprised 140 participants with T2DM (62 men and 78 women, with a median age of 67 years) with a median DM duration of 9.68 years, a mean glycated hemoglobin A1c (HbA1c) value of 7.10%, and a median GA value of 16.10%. As expected, the lower GMI/GA group exhibited higher HbA1c and GA (P < 0.001) with similar mean glucose levels (P = 0.099). GMI/GA values were significantly higher in participants without microvascular complications than in those with microvascular complications, including DKD and/or DR (P < 0.05). After adjusting for confounders, the lowest GMI/GA group (T1) had a 3.601-fold increased risk of microvascular complications (95% CI, 1.364–9.508, P = 0.010) and a 3.830-fold increased risk of DKD, specifically (95% CI, 1.364–12.222, P = 0.023) relative to the highest group (T3). Conclusion GMI/GA serves as a novel risk indicator for microvascular complications in T2DM, independent of HbA1c. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-cfee44cb49084ea7b52ce0b00884af952025-01-26T12:45:29ZengBMCDiabetology & Metabolic Syndrome1758-59962025-01-0117111210.1186/s13098-025-01591-1Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysisYunqi Wu0Binshan Zhang1Xin Ma2Pei Yu3Saijun Zhou4Xinli Wang5NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of EndocrinologyNHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of EndocrinologyNHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of EndocrinologyNHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of EndocrinologyNHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of EndocrinologyNHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of EndocrinologyAbstract Introduction In this study, we assessed whether the ratio of glucose management index (GMI) to glycated albumin (GA) was linked to microvascular complications in patients with type 2 diabetes mellitus (T2DM) who also possessed a shortened erythrocyte lifespan. Methods This study encompassed individuals from the Tianjin Diabetic Retinopathy Screening Cohort who completed continuous glucose monitoring and had an erythrocyte lifespan of under 90 days. Differences in GMI/GA were compared between the T2DM patients with or without microvascular complications, including diabetic kidney disease (DKD) and diabetic retinopathy (DR). The relationship between GMI/GA and microvascular complications (DKD and/or DR) was assessed by dividing GMI/GA into three groups based on tertiles. Results Our study comprised 140 participants with T2DM (62 men and 78 women, with a median age of 67 years) with a median DM duration of 9.68 years, a mean glycated hemoglobin A1c (HbA1c) value of 7.10%, and a median GA value of 16.10%. As expected, the lower GMI/GA group exhibited higher HbA1c and GA (P < 0.001) with similar mean glucose levels (P = 0.099). GMI/GA values were significantly higher in participants without microvascular complications than in those with microvascular complications, including DKD and/or DR (P < 0.05). After adjusting for confounders, the lowest GMI/GA group (T1) had a 3.601-fold increased risk of microvascular complications (95% CI, 1.364–9.508, P = 0.010) and a 3.830-fold increased risk of DKD, specifically (95% CI, 1.364–12.222, P = 0.023) relative to the highest group (T3). Conclusion GMI/GA serves as a novel risk indicator for microvascular complications in T2DM, independent of HbA1c.https://doi.org/10.1186/s13098-025-01591-1Glycation rateGlucose management indexShortened erythrocyte lifespanContinuous glucose monitoringMicrovascular complicationsType 2 diabetes mellitus |
| spellingShingle | Yunqi Wu Binshan Zhang Xin Ma Pei Yu Saijun Zhou Xinli Wang Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis Diabetology & Metabolic Syndrome Glycation rate Glucose management index Shortened erythrocyte lifespan Continuous glucose monitoring Microvascular complications Type 2 diabetes mellitus |
| title | Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis |
| title_full | Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis |
| title_fullStr | Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis |
| title_full_unstemmed | Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis |
| title_short | Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis |
| title_sort | novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan a multicenter cross sectional analysis |
| topic | Glycation rate Glucose management index Shortened erythrocyte lifespan Continuous glucose monitoring Microvascular complications Type 2 diabetes mellitus |
| url | https://doi.org/10.1186/s13098-025-01591-1 |
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