Effect of local radiofrequency hyperthermia on the intratumoral pressure and extracellular matrix stiffness in hepatocellular carcinoma

Effect of local radiofrequency hyperthermia on the intratumoral pressure and extracellular matrix stiffness in hepatocellular carcinoma

Background Increased intratumoral pressure and stiffening of the extracellular matrix are biophysical barriers to effective drug delivery in hepatocellular carcinoma (HCC). Local thermal interventions alter these biophysical characteristics of the tumor.Purpose To characterize time-dependent and the...

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Bibliographic Details
Main Authors: Anna Bottiglieri, Poonam Yadav, Santosh K. Mandal, Malea Williams, Amanda McWatters, Rahul A. Sheth, Punit Prakash
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:International Journal of Hyperthermia
Subjects:
Computational modeling
thermal ablation
intratumoral pressure
tumor stiffness
hepatocellular carcinoma (HCC)
Online Access:https://www.tandfonline.com/doi/10.1080/02656736.2025.2492766
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https://www.tandfonline.com/doi/10.1080/02656736.2025.2492766

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