Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics

Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics

Abstract Deciphering the sources of variability in drug responses requires to understand the processes modulating drug pharmacokinetics. However, pharmacological research suffers from poor reproducibility across clinical, animal, and experimental models. Predictivity can be improved by using Organs-...

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Bibliographic Details
Main Authors: Isy Petit, Quentin Faucher, Jean-Sébastien Bernard, Perrine Giunchi, Antoine Humeau, François-Ludovic Sauvage, Pierre Marquet, Nicolas Védrenne, Florent Di Meo
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Organ-On-a-Chip
Pharmacokinetics
Drug membrane transporters
Proximal tubule-On-a-Chip
Drug-Drug Interactions
Drug-Endogenous metabolite Interactions
Online Access:https://doi.org/10.1038/s41598-025-85653-4
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https://doi.org/10.1038/s41598-025-85653-4

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