Dynamics and control of a mathematical model for metronomic chemotherapy
A $3$-compartment model for metronomic chemotherapy that takes intoaccount cancerous cells, the tumor vasculature and tumorimmune-system interactions is considered as an optimal controlproblem. Metronomic chemo-therapy is the regular, almost continuousadministration of chemotherapeutic agents at low...
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| Language: | English |
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AIMS Press
2015-07-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1257 |
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| author | Urszula Ledzewicz Behrooz Amini Heinz Schättler |
| author_facet | Urszula Ledzewicz Behrooz Amini Heinz Schättler |
| author_sort | Urszula Ledzewicz |
| collection | DOAJ |
| description | A $3$-compartment model for metronomic chemotherapy that takes intoaccount cancerous cells, the tumor vasculature and tumorimmune-system interactions is considered as an optimal controlproblem. Metronomic chemo-therapy is the regular, almost continuousadministration of chemotherapeutic agents at low dose, possibly withsmall interruptions to increase the efficacy of the drugs. Thereexists medical evidence that such administrations of specificcytotoxic agents (e.g., cyclophosphamide) have both antiangiogenicand immune stimulatory effects. A mathematical model for angiogenicsignaling formulated by Hahnfeldt et al. is combined with theclassical equations for tumor immune system interactions byStepanova to form a minimally parameterized model to capture theseeffects of low dose chemotherapy. The model exhibits bistablebehavior with the existence of both benign and malignant locallyasymptotically stable equilibrium points. In this paper, thetransfer of states from the malignant into the benign regions isused as a motivation for the construction of an objective functionalthat induces this process and the analysis of the correspondingoptimal control problem is initiated. |
| format | Article |
| id | doaj-art-cfdc17bd48394f6ab7900f1a4750fb80 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-cfdc17bd48394f6ab7900f1a4750fb802025-01-24T02:33:57ZengAIMS PressMathematical Biosciences and Engineering1551-00182015-07-011261257127510.3934/mbe.2015.12.1257Dynamics and control of a mathematical model for metronomic chemotherapyUrszula Ledzewicz0Behrooz Amini1Heinz Schättler2Dept. of Mathematics and Statistics, Southern Illinois University, Edwardsville, Il 62025Dept. of Mathematics and Statistics, Southern Illinois University, Edwardsville, Il 62025Dept. of Electrical and Systems Engineering, Washington University, St. Louis, Mo 63130A $3$-compartment model for metronomic chemotherapy that takes intoaccount cancerous cells, the tumor vasculature and tumorimmune-system interactions is considered as an optimal controlproblem. Metronomic chemo-therapy is the regular, almost continuousadministration of chemotherapeutic agents at low dose, possibly withsmall interruptions to increase the efficacy of the drugs. Thereexists medical evidence that such administrations of specificcytotoxic agents (e.g., cyclophosphamide) have both antiangiogenicand immune stimulatory effects. A mathematical model for angiogenicsignaling formulated by Hahnfeldt et al. is combined with theclassical equations for tumor immune system interactions byStepanova to form a minimally parameterized model to capture theseeffects of low dose chemotherapy. The model exhibits bistablebehavior with the existence of both benign and malignant locallyasymptotically stable equilibrium points. In this paper, thetransfer of states from the malignant into the benign regions isused as a motivation for the construction of an objective functionalthat induces this process and the analysis of the correspondingoptimal control problem is initiated.https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1257cancer treatmentangiogenic signalingoptimal controltumor immune-system interactions.metronomic chemotherapy |
| spellingShingle | Urszula Ledzewicz Behrooz Amini Heinz Schättler Dynamics and control of a mathematical model for metronomic chemotherapy Mathematical Biosciences and Engineering cancer treatment angiogenic signaling optimal control tumor immune-system interactions. metronomic chemotherapy |
| title | Dynamics and control of a mathematical model for metronomic chemotherapy |
| title_full | Dynamics and control of a mathematical model for metronomic chemotherapy |
| title_fullStr | Dynamics and control of a mathematical model for metronomic chemotherapy |
| title_full_unstemmed | Dynamics and control of a mathematical model for metronomic chemotherapy |
| title_short | Dynamics and control of a mathematical model for metronomic chemotherapy |
| title_sort | dynamics and control of a mathematical model for metronomic chemotherapy |
| topic | cancer treatment angiogenic signaling optimal control tumor immune-system interactions. metronomic chemotherapy |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1257 |
| work_keys_str_mv | AT urszulaledzewicz dynamicsandcontrolofamathematicalmodelformetronomicchemotherapy AT behroozamini dynamicsandcontrolofamathematicalmodelformetronomicchemotherapy AT heinzschattler dynamicsandcontrolofamathematicalmodelformetronomicchemotherapy |