WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis
We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was place...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/193019 |
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| author | Enrico Briguglio Rosanna Di Paola Irene Paterniti Emanuela Mazzon Giacomo Oteri Giancarlo Cordasco Salvatore Cuzzocrea |
| author_facet | Enrico Briguglio Rosanna Di Paola Irene Paterniti Emanuela Mazzon Giacomo Oteri Giancarlo Cordasco Salvatore Cuzzocrea |
| author_sort | Enrico Briguglio |
| collection | DOAJ |
| description | We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis.
Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received WY14643 (1 mg/kg i.p, daily for eight days). Eighths days after placement of the ligature, we evaluated several markers of inflammation such us (1) myeloperoxidase activity, (2) a cytokines and adhesion molecules expression, (3) NF-κB expression, (4) iNOS expression, (5) the nitration of tyrosine residues, (6) activation of the nuclear enzyme poly(ADP-ribose) polymerase, (7) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of WY14643 significantly decreased all of the parameters of inflammation as described above. These results demonstrate that WY14643 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage. |
| format | Article |
| id | doaj-art-cfd697e0be3e4742a446eea134c94620 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-cfd697e0be3e4742a446eea134c946202025-02-03T06:42:19ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/193019193019WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental PeriodontitisEnrico Briguglio0Rosanna Di Paola1Irene Paterniti2Emanuela Mazzon3Giacomo Oteri4Giancarlo Cordasco5Salvatore Cuzzocrea6Istituto Policattedra di Odontostomatologia, Universita degli Studi di Messina, 98100 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, 98100 Messina, ItalyDepartment of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C. Valeria, Gazzi, 98100 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, 98100 Messina, ItalyIstituto Policattedra di Odontostomatologia, Universita degli Studi di Messina, 98100 Messina, ItalyIstituto Policattedra di Odontostomatologia, Universita degli Studi di Messina, 98100 Messina, ItalyIstituto Policattedra di Odontostomatologia, Universita degli Studi di Messina, 98100 Messina, ItalyWe have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received WY14643 (1 mg/kg i.p, daily for eight days). Eighths days after placement of the ligature, we evaluated several markers of inflammation such us (1) myeloperoxidase activity, (2) a cytokines and adhesion molecules expression, (3) NF-κB expression, (4) iNOS expression, (5) the nitration of tyrosine residues, (6) activation of the nuclear enzyme poly(ADP-ribose) polymerase, (7) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of WY14643 significantly decreased all of the parameters of inflammation as described above. These results demonstrate that WY14643 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.http://dx.doi.org/10.1155/2010/193019 |
| spellingShingle | Enrico Briguglio Rosanna Di Paola Irene Paterniti Emanuela Mazzon Giacomo Oteri Giancarlo Cordasco Salvatore Cuzzocrea WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis PPAR Research |
| title | WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis |
| title_full | WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis |
| title_fullStr | WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis |
| title_full_unstemmed | WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis |
| title_short | WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis |
| title_sort | wy 14643 a potent peroxisome proliferator activator receptor α ppar α agonist ameliorates the inflammatory process associated to experimental periodontitis |
| url | http://dx.doi.org/10.1155/2010/193019 |
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