Direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the Regional Reproductive Center materials
Aim. Detection of chromosomal aberrations in patients during spontaneous abortion. Methods and results. Cytogenetic study of chorionic samples of the abortions on first trimester of pregnancy. According to the study, the karyotype anomalies were the cause of cardiac embryonic development in 59% o...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-12-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/52645/49798 |
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| _version_ | 1849396623760687104 |
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| author | N. V. Avramenko D. Ye. Barkovsky I. V. Semenenko N. A. Kalabuchova |
| author_facet | N. V. Avramenko D. Ye. Barkovsky I. V. Semenenko N. A. Kalabuchova |
| author_sort | N. V. Avramenko |
| collection | DOAJ |
| description | Aim. Detection of chromosomal aberrations in patients during spontaneous abortion.
Methods and results. Cytogenetic study of chorionic samples of the abortions on first trimester of pregnancy. According to the study, the karyotype anomalies were the cause of cardiac embryonic development in 59% of cases.
Conclusion. Due to numerous cytogenetic researches of abortion material, anomalies of karyotype are the leading reason of embryonic destruction. The present paper summarizes results of cytogenetic study of the chorionic samples of 26 arrested pregnancies. Frequency and spectrum of karyotype pathology and its correlation with maternal age and term of gestation, sex ratio and type of aberration have been analyzed. The results are compared and discussed with other studies. Most anomalies of karyotype have been conditioned by sporadic genome mutations arising up at ripening of gametes, at an impregnation or in the period of crushing. |
| format | Article |
| id | doaj-art-cfd60c26bfb74c2f8fa1db0508a02dc2 |
| institution | Kabale University |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-cfd60c26bfb74c2f8fa1db0508a02dc22025-08-20T03:39:17ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322015-12-013525610.14739/2409-2932.2015.3.52645Direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the Regional Reproductive Center materialsN. V. AvramenkoD. Ye. BarkovskyI. V. SemenenkoN. A. KalabuchovaAim. Detection of chromosomal aberrations in patients during spontaneous abortion. Methods and results. Cytogenetic study of chorionic samples of the abortions on first trimester of pregnancy. According to the study, the karyotype anomalies were the cause of cardiac embryonic development in 59% of cases. Conclusion. Due to numerous cytogenetic researches of abortion material, anomalies of karyotype are the leading reason of embryonic destruction. The present paper summarizes results of cytogenetic study of the chorionic samples of 26 arrested pregnancies. Frequency and spectrum of karyotype pathology and its correlation with maternal age and term of gestation, sex ratio and type of aberration have been analyzed. The results are compared and discussed with other studies. Most anomalies of karyotype have been conditioned by sporadic genome mutations arising up at ripening of gametes, at an impregnation or in the period of crushing.http://pharmed.zsmu.edu.ua/article/view/52645/49798Arrested PregnancyKaryotypingChromosome And Genomic Mutations |
| spellingShingle | N. V. Avramenko D. Ye. Barkovsky I. V. Semenenko N. A. Kalabuchova Direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the Regional Reproductive Center materials Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Arrested Pregnancy Karyotyping Chromosome And Genomic Mutations |
| title | Direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the Regional Reproductive Center materials |
| title_full | Direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the Regional Reproductive Center materials |
| title_fullStr | Direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the Regional Reproductive Center materials |
| title_full_unstemmed | Direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the Regional Reproductive Center materials |
| title_short | Direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the Regional Reproductive Center materials |
| title_sort | direct cytogenetic study of chorionic samples of the arrested pregnancy tissues according to the regional reproductive center materials |
| topic | Arrested Pregnancy Karyotyping Chromosome And Genomic Mutations |
| url | http://pharmed.zsmu.edu.ua/article/view/52645/49798 |
| work_keys_str_mv | AT nvavramenko directcytogeneticstudyofchorionicsamplesofthearrestedpregnancytissuesaccordingtotheregionalreproductivecentermaterials AT dyebarkovsky directcytogeneticstudyofchorionicsamplesofthearrestedpregnancytissuesaccordingtotheregionalreproductivecentermaterials AT ivsemenenko directcytogeneticstudyofchorionicsamplesofthearrestedpregnancytissuesaccordingtotheregionalreproductivecentermaterials AT nakalabuchova directcytogeneticstudyofchorionicsamplesofthearrestedpregnancytissuesaccordingtotheregionalreproductivecentermaterials |