Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin
<b>Aim: </b>Type 2 Diabetes Mellitus is a metabolic disorder characterized by high blood sugar in case of insulin resistance and/or insulin deficiency or insufficiency. The Wnt/β -catenin signaling pathway plays a role in in all physiological processes. Any defect in the pathway...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1421 |
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| author | Elif Gulbahce-Mutlu Emine Arslan Hilal Arikoglu |
| author_facet | Elif Gulbahce-Mutlu Emine Arslan Hilal Arikoglu |
| author_sort | Elif Gulbahce-Mutlu |
| collection | DOAJ |
| description | <b>Aim: </b>Type 2 Diabetes Mellitus is a metabolic disorder characterized by
high blood sugar in case of insulin resistance and/or insulin deficiency or
insufficiency. The Wnt/β -catenin signaling pathway plays a role in in all
physiological processes. Any defect in the pathway causes diabetes to develop.
The aim of this study was to determine the effect of grape seed extract (GSE) on
body weight, blood glucose and expression of β -catenin gene in experimental
Type 2 diabetic rats.<p>
<b>Materials and Methods:</b> Rats were divided into five groups as Control,
Diabetic Control and Treatment groups (100, 200, 400 mg/kg GSE). The rats
in the diabetes and treatment groups were fed with high-fat diet and were
administered low dose of streptozotocin (35 mg/kg). Body weights of the
rats were recorded weekly during the experiment. The water-soluble extracts
were administered by gavage for four weeks and liver, pancreas and blood
samples taken from animals at the end of treatment were used in the study.<p>
<b>Results:</b> It was observed that the effect of GSE treatment on overall weight
loss due to diabetes was minimal, and 100 and 400 mg/kg GSE doses lowered
blood sugar (p<0.05). According to the results of β -catenin gene expression,
there was no statistically significant difference between the groups in liver
tissue (p>0.05) and pancreatic tissue (p<0.05).<p>
<b>Conclusion: </b>According to the findings, grape seed may be promising in the
treatment of diabetes. |
| format | Article |
| id | doaj-art-cfd44679ed3241bfa7fe325be23f8258 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-cfd44679ed3241bfa7fe325be23f82582025-02-03T11:25:37ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-195339268761421Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocinElif Gulbahce-Mutlu0Emine Arslan1Hilal Arikoglu2KTO Karatay University, Faculty of Medicine, Department of Medical Biology, Konya, TürkiyeSelcuk University, Faculty of Science, Department of Biology, Konya, TürkiyeSelçuk University, Faculty of Medicine, Department of Medical Biology, Konya, Türkiye<b>Aim: </b>Type 2 Diabetes Mellitus is a metabolic disorder characterized by high blood sugar in case of insulin resistance and/or insulin deficiency or insufficiency. The Wnt/β -catenin signaling pathway plays a role in in all physiological processes. Any defect in the pathway causes diabetes to develop. The aim of this study was to determine the effect of grape seed extract (GSE) on body weight, blood glucose and expression of β -catenin gene in experimental Type 2 diabetic rats.<p> <b>Materials and Methods:</b> Rats were divided into five groups as Control, Diabetic Control and Treatment groups (100, 200, 400 mg/kg GSE). The rats in the diabetes and treatment groups were fed with high-fat diet and were administered low dose of streptozotocin (35 mg/kg). Body weights of the rats were recorded weekly during the experiment. The water-soluble extracts were administered by gavage for four weeks and liver, pancreas and blood samples taken from animals at the end of treatment were used in the study.<p> <b>Results:</b> It was observed that the effect of GSE treatment on overall weight loss due to diabetes was minimal, and 100 and 400 mg/kg GSE doses lowered blood sugar (p<0.05). According to the results of β -catenin gene expression, there was no statistically significant difference between the groups in liver tissue (p>0.05) and pancreatic tissue (p<0.05).<p> <b>Conclusion: </b>According to the findings, grape seed may be promising in the treatment of diabetes.http://eurasianjvetsci.org/pdf.php3?id=1421β -catenintype 2 diabetes mellitusgene expressionstreptozotocingrape seed extract |
| spellingShingle | Elif Gulbahce-Mutlu Emine Arslan Hilal Arikoglu Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin Eurasian Journal of Veterinary Sciences β -catenin type 2 diabetes mellitus gene expression streptozotocin grape seed extract |
| title | Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin |
| title_full | Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin |
| title_fullStr | Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin |
| title_full_unstemmed | Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin |
| title_short | Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin |
| title_sort | effect of grape seed extract on 946 catenin gene expression and hyperglycemia in rats induced by streptozotocin |
| topic | β -catenin type 2 diabetes mellitus gene expression streptozotocin grape seed extract |
| url | http://eurasianjvetsci.org/pdf.php3?id=1421 |
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