Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice.

Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice.

Nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) is required for the conversion of extracellular ATP into inorganic pyrophosphate (PP(i)), a recognised inhibitor of hydroxyapatite (HA) crystal formation. A detailed phenotypic assessment of a mouse model lacking NPP1 (Enpp1(-/-)) was completed t...

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Bibliographic Details
Main Authors: Neil Charles Wallace Mackenzie, Dongxing Zhu, Elspeth M Milne, Rob van 't Hof, Aline Martin, Leigh Darryl Quarles, José Luis Millán, Colin Farquharson, Vicky Elisabeth MacRae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032177&type=printable
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