Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective
Background and Aim: The emergence and global dissemination of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli represent a major public health concern. While antibiotic resistance in clinical and agricultural settings is well documented, the contribution of wildlife, particularly bats...
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Veterinary World
2025-05-01
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| Series: | Veterinary World |
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| Online Access: | https://www.veterinaryworld.org/Vol.18/May-2025/12.pdf |
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| author | Alfiana Laili Dwi Agustin Aswin Rafif Khairullah Mustofa Helmi Effendi Wiwiek Tyasningsih Ikechukwu Benjamin Moses Budiastuti Budiastuti Hani Plumeriastuti Sheila Marty Yanestria Katty Hendriana Priscilia Riwu Fidi Nur Aini Eka Puji Dameanti Wasito Wasito Riza Zainuddin Ahmad Agus Widodo Daniah Ashri Afnani |
| author_facet | Alfiana Laili Dwi Agustin Aswin Rafif Khairullah Mustofa Helmi Effendi Wiwiek Tyasningsih Ikechukwu Benjamin Moses Budiastuti Budiastuti Hani Plumeriastuti Sheila Marty Yanestria Katty Hendriana Priscilia Riwu Fidi Nur Aini Eka Puji Dameanti Wasito Wasito Riza Zainuddin Ahmad Agus Widodo Daniah Ashri Afnani |
| author_sort | Alfiana Laili Dwi Agustin |
| collection | DOAJ |
| description | Background and Aim: The emergence and global dissemination of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli represent a major public health concern. While antibiotic resistance in clinical and agricultural settings is well documented, the contribution of wildlife, particularly bats, to the spread of antimicrobial resistance (AMR) remains underexplored. Bats possess unique ecological traits – such as long-distance flight, longevity, and adaptability – that facilitate their role as potential reservoirs and vectors of antibiotic-resistant bacteria. This review synthesizes global findings on the occurrence, genetic characteristics, and transmission dynamics of ESBL-producing E. coli isolated from bats. Through a comprehensive literature review of studies conducted across five continents, we highlight the prevalence of multidrug-resistant E. coli in bat populations, with resistance profiles frequently including β-lactams (bla), aminoglycosides, tetracyclines, and fluoroquinolones. Notably, key ESBL genes such as blaCTX-M, blaTEM, blaSHV, and blaOXA have been identified in isolates from bat feces (guano), raising significant concern due to potential environmental contamination and zoonotic spillover. Risk factors such as habitat encroachment, anthropogenic waste exposure, and the agricultural use of bat guano further exacerbate the risk of ESBL transmission. Moreover, genomic comparisons suggest phylogenetic overlap between ESBL-producing E. coli from bats and those found in humans and livestock. Given these findings, bats warrant greater inclusion in One Health surveillance frameworks to trace AMR gene flow and develop targeted interventions. This review underscores the need for integrated AMR monitoring in wildlife, enhanced waste management policies, and stricter biosecurity to mitigate the public health risks associated with wildlife-origin ESBL dissemination. |
| format | Article |
| id | doaj-art-cfca29103af6493f9512a388cff9884c |
| institution | OA Journals |
| issn | 0972-8988 2231-0916 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Veterinary World |
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| series | Veterinary World |
| spelling | doaj-art-cfca29103af6493f9512a388cff9884c2025-08-20T02:32:09ZengVeterinary WorldVeterinary World0972-89882231-09162025-05-011851199121310.14202/vetworld.2025.1199-1213Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspectiveAlfiana Laili Dwi Agustin0https://orcid.org/0000-0002-5467-6167Aswin Rafif Khairullah1https://orcid.org/0000-0001-9421-9342Mustofa Helmi Effendi2https://orcid.org/0000-0001-9727-411XWiwiek Tyasningsih3https://orcid.org/0000-0003-0604-8534Ikechukwu Benjamin Moses4https://orcid.org/0000-0002-5928-8198Budiastuti Budiastuti5https://orcid.org/0000-0002-3065-4617Hani Plumeriastuti6https://orcid.org/0000-0002-4540-811XSheila Marty Yanestria7https://orcid.org/0000-0002-2514-1104Katty Hendriana Priscilia Riwu8https://orcid.org/0000-0003-0395-2296Fidi Nur Aini Eka Puji Dameanti9https://orcid.org/0000-0002-7928-1073Wasito Wasito10https://orcid.org/0000-0003-1673-4482Riza Zainuddin Ahmad11https://orcid.org/0000-0002-2067-717XAgus Widodo12https://orcid.org/0000-0003-3255-6188Daniah Ashri Afnani13https://orcid.org/0000-0003-0719-6061Doctoral Program of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya, 60115, East Java, Indonesia; Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl. Pemuda No. 59A, Dasan Agung Baru, Mataram, 83125, West Nusa Tenggara, Indonesia.Research Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya, 60115, East Java, Indonesia.Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya, 60115, East Java, Indonesia.Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Abakaliki, 480211, Nigeria.Study Program of Pharmacy Science, Faculty of Health Science, Universitas Muhammadiyah Surabaya, Jl. Raya Sutorejo No.59, Dukuh Sutorejo, Mulyorejo, Surabaya, 60113, East Java, Indonesia.Department of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya, 60115, East Java, Indonesia.Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Wijaya Kusuma Surabaya, Jl. Dukuh Kupang XXV No.54, Dukuh Kupang, Dukuh Pakis, Surabaya, 60225, East Java, Indonesia.Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl. Pemuda No. 59A, Dasan Agung Baru, Mataram, 83125, West Nusa Tenggara, Indonesia.Laboratory of Veterinary Microbiology and Immunology, Faculty of Veterinary Medicine, Universitas Brawijaya, Jl. Puncak Dieng, Kunci, Kalisongo, Dau, Malang, 65151, East Java, Indonesia.Research Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Jl. Dharmawangsa Dalam Selatan No. 28-30, Kampus B Airlangga, Surabaya, 60115, East Java, Indonesia.Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Jl. Pemuda No. 59A, Dasan Agung Baru, Mataram, 83125, West Nusa Tenggara, Indonesia.Background and Aim: The emergence and global dissemination of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli represent a major public health concern. While antibiotic resistance in clinical and agricultural settings is well documented, the contribution of wildlife, particularly bats, to the spread of antimicrobial resistance (AMR) remains underexplored. Bats possess unique ecological traits – such as long-distance flight, longevity, and adaptability – that facilitate their role as potential reservoirs and vectors of antibiotic-resistant bacteria. This review synthesizes global findings on the occurrence, genetic characteristics, and transmission dynamics of ESBL-producing E. coli isolated from bats. Through a comprehensive literature review of studies conducted across five continents, we highlight the prevalence of multidrug-resistant E. coli in bat populations, with resistance profiles frequently including β-lactams (bla), aminoglycosides, tetracyclines, and fluoroquinolones. Notably, key ESBL genes such as blaCTX-M, blaTEM, blaSHV, and blaOXA have been identified in isolates from bat feces (guano), raising significant concern due to potential environmental contamination and zoonotic spillover. Risk factors such as habitat encroachment, anthropogenic waste exposure, and the agricultural use of bat guano further exacerbate the risk of ESBL transmission. Moreover, genomic comparisons suggest phylogenetic overlap between ESBL-producing E. coli from bats and those found in humans and livestock. Given these findings, bats warrant greater inclusion in One Health surveillance frameworks to trace AMR gene flow and develop targeted interventions. This review underscores the need for integrated AMR monitoring in wildlife, enhanced waste management policies, and stricter biosecurity to mitigate the public health risks associated with wildlife-origin ESBL dissemination.https://www.veterinaryworld.org/Vol.18/May-2025/12.pdfantibiotic resistancebatsescherichia coliextended-spectrum β-lactamaseguanoone healthsurveillancezoonosis |
| spellingShingle | Alfiana Laili Dwi Agustin Aswin Rafif Khairullah Mustofa Helmi Effendi Wiwiek Tyasningsih Ikechukwu Benjamin Moses Budiastuti Budiastuti Hani Plumeriastuti Sheila Marty Yanestria Katty Hendriana Priscilia Riwu Fidi Nur Aini Eka Puji Dameanti Wasito Wasito Riza Zainuddin Ahmad Agus Widodo Daniah Ashri Afnani Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective Veterinary World antibiotic resistance bats escherichia coli extended-spectrum β-lactamase guano one health surveillance zoonosis |
| title | Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective |
| title_full | Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective |
| title_fullStr | Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective |
| title_full_unstemmed | Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective |
| title_short | Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective |
| title_sort | ecological and public health dimensions of esbl producing escherichia coli in bats a one health perspective |
| topic | antibiotic resistance bats escherichia coli extended-spectrum β-lactamase guano one health surveillance zoonosis |
| url | https://www.veterinaryworld.org/Vol.18/May-2025/12.pdf |
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