Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras
Inherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities of the myocardium. Understanding genotype–phenotype correlations in these conditions is vital for personalized cardiac medicine, enabling targete...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Saudi Journal for Health Sciences |
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| Online Access: | https://journals.lww.com/10.4103/sjhs.sjhs_95_24 |
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| author | Yaqob Samir Taleb Paras Memon Aftab Jalbani Nawaf Al-Anazi Abdulkareem Al-Garni Muneera Altaweel Muhammad Aamir Khan Muhammad Farooq Sabar Zafar Iqbal |
| author_facet | Yaqob Samir Taleb Paras Memon Aftab Jalbani Nawaf Al-Anazi Abdulkareem Al-Garni Muneera Altaweel Muhammad Aamir Khan Muhammad Farooq Sabar Zafar Iqbal |
| author_sort | Yaqob Samir Taleb |
| collection | DOAJ |
| description | Inherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities of the myocardium. Understanding genotype–phenotype correlations in these conditions is vital for personalized cardiac medicine, enabling targeted therapeutic strategies and predictive diagnostics. This review explores the major types of inherited cardiomyopathies–hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic cardiomyopathy, and restrictive cardiomyopathy–and provides detailed insights into how different genetic mutations manifest as clinical features. The integration of multi-omics approaches and advanced disease modeling techniques has enhanced our ability to dissect these correlations. The review also discusses the implications of these findings for personalized medicine, including tailored therapeutic strategies, predictive diagnostics, and future research directions. |
| format | Article |
| id | doaj-art-cfc8fa63b7fe4dbab8ea997fa4e1b710 |
| institution | OA Journals |
| issn | 2278-1900 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal for Health Sciences |
| spelling | doaj-art-cfc8fa63b7fe4dbab8ea997fa4e1b7102025-08-20T02:11:05ZengWolters Kluwer Medknow PublicationsSaudi Journal for Health Sciences2278-19002025-01-01141304110.4103/sjhs.sjhs_95_24Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling erasYaqob Samir TalebParas MemonAftab JalbaniNawaf Al-AnaziAbdulkareem Al-GarniMuneera AltaweelMuhammad Aamir KhanMuhammad Farooq SabarZafar IqbalInherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities of the myocardium. Understanding genotype–phenotype correlations in these conditions is vital for personalized cardiac medicine, enabling targeted therapeutic strategies and predictive diagnostics. This review explores the major types of inherited cardiomyopathies–hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic cardiomyopathy, and restrictive cardiomyopathy–and provides detailed insights into how different genetic mutations manifest as clinical features. The integration of multi-omics approaches and advanced disease modeling techniques has enhanced our ability to dissect these correlations. The review also discusses the implications of these findings for personalized medicine, including tailored therapeutic strategies, predictive diagnostics, and future research directions.https://journals.lww.com/10.4103/sjhs.sjhs_95_24cardiomyopathygenetic testingmulti-omics techniquespersonalized medicine |
| spellingShingle | Yaqob Samir Taleb Paras Memon Aftab Jalbani Nawaf Al-Anazi Abdulkareem Al-Garni Muneera Altaweel Muhammad Aamir Khan Muhammad Farooq Sabar Zafar Iqbal Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras Saudi Journal for Health Sciences cardiomyopathy genetic testing multi-omics techniques personalized medicine |
| title | Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras |
| title_full | Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras |
| title_fullStr | Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras |
| title_full_unstemmed | Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras |
| title_short | Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras |
| title_sort | genotype phenotype correlations in inherited cardiomyopathies their role in clinical decision making and implications in personalized cardiac medicine in multi omics as well as disease modeling eras |
| topic | cardiomyopathy genetic testing multi-omics techniques personalized medicine |
| url | https://journals.lww.com/10.4103/sjhs.sjhs_95_24 |
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