Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials
Background: Functional dyspepsia (FD) is the most prevalent pediatric gastrointestinal disorder, imposing a significant burden on healthcare services and often persisting into adulthood. Tuina, a traditional manual therapy, is frequently employed in the treatment of FD. This study aimed to systemati...
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Elsevier
2025-03-01
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| Series: | Complementary Therapies in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229924001055 |
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| author | Na-Yeon Ha Chang-Yul Keum Jinsung Kim |
| author_facet | Na-Yeon Ha Chang-Yul Keum Jinsung Kim |
| author_sort | Na-Yeon Ha |
| collection | DOAJ |
| description | Background: Functional dyspepsia (FD) is the most prevalent pediatric gastrointestinal disorder, imposing a significant burden on healthcare services and often persisting into adulthood. Tuina, a traditional manual therapy, is frequently employed in the treatment of FD. This study aimed to systematically evaluate the efficacy and safety of Tuina in treating FD in children. Methods: A comprehensive search of 11 databases was conducted for randomized controlled trials (RCTs) published up to June 2022. Two independent reviewers screened the literature, extracted data, assessed the methodological quality of the RCTs using the Cochrane risk-of-bias tool, and performed meta-analysis using Review Manager software to quantify Tuina’s efficacy. Results: The review covered ten RCTs with 1336 children. Tuina, alone or with conventional therapy (CT), significantly improved efficacy rates over CT alone (relative risk (RR) = 1.16, 95 % confidence interval (CI) [1.11, 1.21], p < 0.00001). The combined Tuina group demonstrated significantly lower overall dyspeptic symptom scores (standard mean difference (SMD) = -1.18, 95 % CI [-1.46, −0.91], p < 0.00001) and shorter times to resolution of primary symptoms, including abdominal distension (mean difference (MD) = -2.08, 95 % CI [-2.35, −1.81], p < 0.00001), abdominal pain (MD = −1.54, 95 % CI [-1.92, −1.17], p < 0.00001), belching (MD = −1.11, 95 % CI [-1.44, −0.77], p < 0.00001), and anorexia (MD = −1.37, 95 % CI [-1.67, −1.07], p < 0.00001). Additionally, the recurrence rate following treatment was significantly lower (RR = 0.32, 95 % CI [0.14, 0.72], p = 0.006). The levels of serum motilin (MD = 22.93, 95 % CI [13.56, 32.30], p < 0.00001) and urinary excretion of D-xylose (MD = 3.11, 95 % CI [0.31, 5.92], p = 0.03) were also elevated. There were no significant differences between the combined Tuina and CT groups regarding the four individual dyspeptic symptoms or neuropeptide Y levels. No adverse events were reported in the Tuina group. Conclusion: This systematic review collectively suggest that Tuina effectively and safely improves clinical symptoms in children with FD. However, addressing identified methodological weaknesses is crucial for future studies to ensure robust evidence. |
| format | Article |
| id | doaj-art-cfc6184de8a040729fc6311a863b5486 |
| institution | Kabale University |
| issn | 0965-2299 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | Complementary Therapies in Medicine |
| spelling | doaj-art-cfc6184de8a040729fc6311a863b54862025-01-30T05:12:51ZengElsevierComplementary Therapies in Medicine0965-22992025-03-0188103117Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trialsNa-Yeon Ha0Chang-Yul Keum1Jinsung Kim2Division of Digestive Diseases, Department of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Department of Digestive Diseases, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of KoreaDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of KoreaDivision of Digestive Diseases, Department of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Department of Digestive Diseases, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Corresponding author at: Department of Digestive Diseases, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.Background: Functional dyspepsia (FD) is the most prevalent pediatric gastrointestinal disorder, imposing a significant burden on healthcare services and often persisting into adulthood. Tuina, a traditional manual therapy, is frequently employed in the treatment of FD. This study aimed to systematically evaluate the efficacy and safety of Tuina in treating FD in children. Methods: A comprehensive search of 11 databases was conducted for randomized controlled trials (RCTs) published up to June 2022. Two independent reviewers screened the literature, extracted data, assessed the methodological quality of the RCTs using the Cochrane risk-of-bias tool, and performed meta-analysis using Review Manager software to quantify Tuina’s efficacy. Results: The review covered ten RCTs with 1336 children. Tuina, alone or with conventional therapy (CT), significantly improved efficacy rates over CT alone (relative risk (RR) = 1.16, 95 % confidence interval (CI) [1.11, 1.21], p < 0.00001). The combined Tuina group demonstrated significantly lower overall dyspeptic symptom scores (standard mean difference (SMD) = -1.18, 95 % CI [-1.46, −0.91], p < 0.00001) and shorter times to resolution of primary symptoms, including abdominal distension (mean difference (MD) = -2.08, 95 % CI [-2.35, −1.81], p < 0.00001), abdominal pain (MD = −1.54, 95 % CI [-1.92, −1.17], p < 0.00001), belching (MD = −1.11, 95 % CI [-1.44, −0.77], p < 0.00001), and anorexia (MD = −1.37, 95 % CI [-1.67, −1.07], p < 0.00001). Additionally, the recurrence rate following treatment was significantly lower (RR = 0.32, 95 % CI [0.14, 0.72], p = 0.006). The levels of serum motilin (MD = 22.93, 95 % CI [13.56, 32.30], p < 0.00001) and urinary excretion of D-xylose (MD = 3.11, 95 % CI [0.31, 5.92], p = 0.03) were also elevated. There were no significant differences between the combined Tuina and CT groups regarding the four individual dyspeptic symptoms or neuropeptide Y levels. No adverse events were reported in the Tuina group. Conclusion: This systematic review collectively suggest that Tuina effectively and safely improves clinical symptoms in children with FD. However, addressing identified methodological weaknesses is crucial for future studies to ensure robust evidence.http://www.sciencedirect.com/science/article/pii/S0965229924001055Functional dyspepsiaTuinaChunaMassageManual medicineMeta-analysis |
| spellingShingle | Na-Yeon Ha Chang-Yul Keum Jinsung Kim Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials Complementary Therapies in Medicine Functional dyspepsia Tuina Chuna Massage Manual medicine Meta-analysis |
| title | Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials |
| title_full | Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials |
| title_short | Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials |
| title_sort | pediatric tuina for the treatment of functional dyspepsia a systematic review and meta analysis of randomized controlled trials |
| topic | Functional dyspepsia Tuina Chuna Massage Manual medicine Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0965229924001055 |
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