Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experience
Abstract Introduction Radiation induced urethral stenosis disease represents a complex subset of patients with higher rates of recurrence after treatment. Optilume®, a Paclitaxel drug-coated balloon, has been utilized in anterior urethral strictures with promising results. Although urethroplasty is...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Urology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12894-025-01829-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract Introduction Radiation induced urethral stenosis disease represents a complex subset of patients with higher rates of recurrence after treatment. Optilume®, a Paclitaxel drug-coated balloon, has been utilized in anterior urethral strictures with promising results. Although urethroplasty is traditionally regarded as the gold standard for treating radiation-induced posterior urethral stenosis, it can be an invasive and challenging procedure with potential side effects. We aim to evaluate the efficacy of the Optilume® drug-coated balloon as a minimally invasive treatment option for radiation-induced posterior urethral stenosis. Methods A retrospective, multi-institutional review was conducted on male patients who underwent Optilume® drug-coated balloon dilation from January 1, 2022, to November 1, 2023. The study involved five surgeons across four institutions. Patients were investigated based on their history of radiation-induced posterior urethral stenosis, and comparisons were made regarding demographics, characteristics of urethral stenosis, and outcomes, including surgical success and complications. Results Among the 56 patients with radiation-induced posterior urethral stenosis evaluated across all four institutions, 37 men had at least 90-day follow-up data. Of these 37 patients, 30 (81.1%) were deemed successful, defined as being free from repeat intervention. Although 6 patients (10.7%) experienced complications, none were greater than Clavien IIIb, with the most common complication being acute urinary retention. Conclusion Although radiation-induced urethral stenosis is typically associated with high rates of recurrence following conservative treatment, Optilume® drug-coated balloon represents an alternative endoscopic treatment option with encouraging short-term results. |
|---|---|
| ISSN: | 1471-2490 |