From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules
Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation. These biopolymers exhibit a broad molecular weight (MW) range, t...
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2025-01-01
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| author | Cíntia Marques Alexandre Porcello Marco Cerrano Farid Hadjab Michèle Chemali Kelly Lourenço Basste Hadjab Wassim Raffoul Lee Ann Applegate Alexis E. Laurent |
| author_facet | Cíntia Marques Alexandre Porcello Marco Cerrano Farid Hadjab Michèle Chemali Kelly Lourenço Basste Hadjab Wassim Raffoul Lee Ann Applegate Alexis E. Laurent |
| author_sort | Cíntia Marques |
| collection | DOAJ |
| description | Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation. These biopolymers exhibit a broad molecular weight (MW) range, typically spanning from 50 to 1500 kDa. However, recent studies have expanded this range to encompass fragments as small as 1 kDa and as large as 10,000 kDa. Clinically, PDRN/PN formulations, commercially available in various galenic forms (gels, creams, serums, masks, and injectables), have demonstrated promising effects in significantly promoting skin regeneration, reducing inflammation, improving skin texture, preventing scar formation, and mitigating wrinkles. Importantly, despite their widespread use in cosmetology and aesthetic dermatology, the interchangeable use of the terms “PDRN” and “PN” in the scientific literature (to describe polymers of varying lengths) has led to considerable confusion within the medical and scientific communities. To specifically address this PDRN/PN ambiguity, this narrative review proposes a standardized structure-based nomenclature for these DNA-derived polymers, the “Marques Polynucleotide Cutoff”, set at 1500 kDa. Thus, we propose that the term “PDRN” should be exclusively reserved for small- and medium-chain polymers (MW < 1500 kDa), while the term “PN” should specifically be used to denote longer-chain polymers (MW ≥ 1500 kDa). In a broader perspective, this classification is based on the distinct physicochemical properties and therapeutic effects of these DNA fragments of various MWs, which are comprehensively discussed in the present review. |
| format | Article |
| id | doaj-art-cfb4b78fc5644b37b8e53141c9b40840 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-cfb4b78fc5644b37b8e53141c9b408402025-01-24T13:25:22ZengMDPI AGBiomolecules2218-273X2025-01-0115114810.3390/biom15010148From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional BiomoleculesCíntia Marques0Alexandre Porcello1Marco Cerrano2Farid Hadjab3Michèle Chemali4Kelly Lourenço5Basste Hadjab6Wassim Raffoul7Lee Ann Applegate8Alexis E. Laurent9Development Department, LOUNA REGENERATIVE SA, CH-1207 Geneva, SwitzerlandDevelopment Department, LOUNA REGENERATIVE SA, CH-1207 Geneva, SwitzerlandAesthetic Surgery Department, Clinique Entourage, CH-1003 Lausanne, SwitzerlandDevelopment Department, Albomed GmbH, D-90592 Schwarzenbruck, GermanyPlastic and Aesthetic Surgery Service, Centre Médical Lausanne Ouest, CH-1008 Prilly, SwitzerlandDevelopment Department, LOUNA REGENERATIVE SA, CH-1207 Geneva, SwitzerlandIndependent Consultant Office, F-74330 Poisy, FrancePlastic and Reconstructive Surgery Service, Ensemble Hospitalier de la Côte, CH-1110 Morges, SwitzerlandRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, SwitzerlandRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, SwitzerlandPolydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing and skin rejuvenation. These biopolymers exhibit a broad molecular weight (MW) range, typically spanning from 50 to 1500 kDa. However, recent studies have expanded this range to encompass fragments as small as 1 kDa and as large as 10,000 kDa. Clinically, PDRN/PN formulations, commercially available in various galenic forms (gels, creams, serums, masks, and injectables), have demonstrated promising effects in significantly promoting skin regeneration, reducing inflammation, improving skin texture, preventing scar formation, and mitigating wrinkles. Importantly, despite their widespread use in cosmetology and aesthetic dermatology, the interchangeable use of the terms “PDRN” and “PN” in the scientific literature (to describe polymers of varying lengths) has led to considerable confusion within the medical and scientific communities. To specifically address this PDRN/PN ambiguity, this narrative review proposes a standardized structure-based nomenclature for these DNA-derived polymers, the “Marques Polynucleotide Cutoff”, set at 1500 kDa. Thus, we propose that the term “PDRN” should be exclusively reserved for small- and medium-chain polymers (MW < 1500 kDa), while the term “PN” should specifically be used to denote longer-chain polymers (MW ≥ 1500 kDa). In a broader perspective, this classification is based on the distinct physicochemical properties and therapeutic effects of these DNA fragments of various MWs, which are comprehensively discussed in the present review.https://www.mdpi.com/2218-273X/15/1/148anti-agingDNA fragmentsmolecular weightnomenclaturephysicochemical propertiespolydeoxyribonucleotides (PDRNs) |
| spellingShingle | Cíntia Marques Alexandre Porcello Marco Cerrano Farid Hadjab Michèle Chemali Kelly Lourenço Basste Hadjab Wassim Raffoul Lee Ann Applegate Alexis E. Laurent From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules Biomolecules anti-aging DNA fragments molecular weight nomenclature physicochemical properties polydeoxyribonucleotides (PDRNs) |
| title | From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules |
| title_full | From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules |
| title_fullStr | From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules |
| title_full_unstemmed | From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules |
| title_short | From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules |
| title_sort | from polydeoxyribonucleotides pdrns to polynucleotides pns bridging the gap between scientific definitions molecular insights and clinical applications of multifunctional biomolecules |
| topic | anti-aging DNA fragments molecular weight nomenclature physicochemical properties polydeoxyribonucleotides (PDRNs) |
| url | https://www.mdpi.com/2218-273X/15/1/148 |
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