Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment
Obesity has emerged as a global epidemic with far-reaching health complications, including its role as an independent risk factor for chronic kidney disease (CKD). Increasing evidence suggests that obesity contributes to CKD through multiple mechanisms, including chronic inflammation, hemodynamic al...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/2/169 |
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| author | Elena Avgoustou Ilektra Tzivaki Garyfalia Diamantopoulou Tatiana Zachariadou Despoina Avramidou Vasileios Dalopoulos Alexandros Skourtis |
| author_facet | Elena Avgoustou Ilektra Tzivaki Garyfalia Diamantopoulou Tatiana Zachariadou Despoina Avramidou Vasileios Dalopoulos Alexandros Skourtis |
| author_sort | Elena Avgoustou |
| collection | DOAJ |
| description | Obesity has emerged as a global epidemic with far-reaching health complications, including its role as an independent risk factor for chronic kidney disease (CKD). Increasing evidence suggests that obesity contributes to CKD through multiple mechanisms, including chronic inflammation, hemodynamic alterations, insulin resistance, and lipid accumulation. These processes can culminate in histopathological changes collectively referred to as obesity-related glomerulopathy (ORG). This review aims to provide a comprehensive overview of the current knowledge regarding the prevalence, clinical manifestations, and pathophysiology of ORG. Furthermore, we emphasize the importance of identifying key biomarkers that facilitate the early detection of ORG. Finally, we explore emerging therapeutic strategies that offer promise in mitigating this growing global health crisis. |
| format | Article |
| id | doaj-art-cfa377200b65490a894fdde4c5614d58 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-cfa377200b65490a894fdde4c5614d582025-01-24T13:28:59ZengMDPI AGDiagnostics2075-44182025-01-0115216910.3390/diagnostics15020169Obesity-Related Chronic Kidney Disease: From Diagnosis to TreatmentElena Avgoustou0Ilektra Tzivaki1Garyfalia Diamantopoulou2Tatiana Zachariadou3Despoina Avramidou4Vasileios Dalopoulos5Alexandros Skourtis6Second Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokratio General Hospital, Vasilissis Sofias 114, 11527 Athens, GreeceFirst Department of Internal Medicine, Sismanogleio General Hospital, 37 Sismanogliou Str., 15126 Athens, GreeceSecond Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokratio General Hospital, Vasilissis Sofias 114, 11527 Athens, GreeceFirst Department of Internal Medicine, Sismanogleio General Hospital, 37 Sismanogliou Str., 15126 Athens, GreeceSecond Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokratio General Hospital, Vasilissis Sofias 114, 11527 Athens, GreeceFirst Department of Internal Medicine, Sismanogleio General Hospital, 37 Sismanogliou Str., 15126 Athens, GreeceDepartment of Internal Medicine, Evangelismos General Hospital, 45-47 Ipsilantou Str., 10676 Athens, GreeceObesity has emerged as a global epidemic with far-reaching health complications, including its role as an independent risk factor for chronic kidney disease (CKD). Increasing evidence suggests that obesity contributes to CKD through multiple mechanisms, including chronic inflammation, hemodynamic alterations, insulin resistance, and lipid accumulation. These processes can culminate in histopathological changes collectively referred to as obesity-related glomerulopathy (ORG). This review aims to provide a comprehensive overview of the current knowledge regarding the prevalence, clinical manifestations, and pathophysiology of ORG. Furthermore, we emphasize the importance of identifying key biomarkers that facilitate the early detection of ORG. Finally, we explore emerging therapeutic strategies that offer promise in mitigating this growing global health crisis.https://www.mdpi.com/2075-4418/15/2/169obesitychronic kidney diseaseobesity-related glomerulopathybiomarkersRAAS blockadeectopic lipid accumulation |
| spellingShingle | Elena Avgoustou Ilektra Tzivaki Garyfalia Diamantopoulou Tatiana Zachariadou Despoina Avramidou Vasileios Dalopoulos Alexandros Skourtis Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment Diagnostics obesity chronic kidney disease obesity-related glomerulopathy biomarkers RAAS blockade ectopic lipid accumulation |
| title | Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment |
| title_full | Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment |
| title_fullStr | Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment |
| title_full_unstemmed | Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment |
| title_short | Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment |
| title_sort | obesity related chronic kidney disease from diagnosis to treatment |
| topic | obesity chronic kidney disease obesity-related glomerulopathy biomarkers RAAS blockade ectopic lipid accumulation |
| url | https://www.mdpi.com/2075-4418/15/2/169 |
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