Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole Body

This paper describes an automated procedure for creating detailed patient-specific pediatric dosimetry phantoms from a small set of segmented organs in a child's CT scan. The algorithm involves full body mappings from adult template to pediatric images using multichannel large deformation diffe...

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Main Authors: Daniel J. Tward, Can Ceritoglu, Anthony Kolasny, Gregory M. Sturgeon, W. Paul Segars, Michael I. Miller, J. Tilak Ratnanather
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:International Journal of Biomedical Imaging
Online Access:http://dx.doi.org/10.1155/2011/481064
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author Daniel J. Tward
Can Ceritoglu
Anthony Kolasny
Gregory M. Sturgeon
W. Paul Segars
Michael I. Miller
J. Tilak Ratnanather
author_facet Daniel J. Tward
Can Ceritoglu
Anthony Kolasny
Gregory M. Sturgeon
W. Paul Segars
Michael I. Miller
J. Tilak Ratnanather
author_sort Daniel J. Tward
collection DOAJ
description This paper describes an automated procedure for creating detailed patient-specific pediatric dosimetry phantoms from a small set of segmented organs in a child's CT scan. The algorithm involves full body mappings from adult template to pediatric images using multichannel large deformation diffeomorphic metric mapping (MC-LDDMM). The parallel implementation and performance of MC-LDDMM for this application is studied here for a sample of 4 pediatric patients, and from 1 to 24 processors. 93.84% of computation time is parallelized, and the efficiency of parallelization remains high until more than 8 processors are used. The performance of the algorithm was validated on a set of 24 male and 18 female pediatric patients. It was found to be accurate typically to within 1-2 voxels (2–4 mm) and robust across this large and variable data set.
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publishDate 2011-01-01
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spelling doaj-art-cfa0dcbfc1514399b83e5ed32ceadbaf2025-08-20T02:20:07ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962011-01-01201110.1155/2011/481064481064Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole BodyDaniel J. Tward0Can Ceritoglu1Anthony Kolasny2Gregory M. Sturgeon3W. Paul Segars4Michael I. Miller5J. Tilak Ratnanather6The Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218-2686, USAThe Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218-2686, USAThe Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218-2686, USACarl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, NC 27705, USACarl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, NC 27705, USAThe Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218-2686, USAThe Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218-2686, USAThis paper describes an automated procedure for creating detailed patient-specific pediatric dosimetry phantoms from a small set of segmented organs in a child's CT scan. The algorithm involves full body mappings from adult template to pediatric images using multichannel large deformation diffeomorphic metric mapping (MC-LDDMM). The parallel implementation and performance of MC-LDDMM for this application is studied here for a sample of 4 pediatric patients, and from 1 to 24 processors. 93.84% of computation time is parallelized, and the efficiency of parallelization remains high until more than 8 processors are used. The performance of the algorithm was validated on a set of 24 male and 18 female pediatric patients. It was found to be accurate typically to within 1-2 voxels (2–4 mm) and robust across this large and variable data set.http://dx.doi.org/10.1155/2011/481064
spellingShingle Daniel J. Tward
Can Ceritoglu
Anthony Kolasny
Gregory M. Sturgeon
W. Paul Segars
Michael I. Miller
J. Tilak Ratnanather
Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole Body
International Journal of Biomedical Imaging
title Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole Body
title_full Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole Body
title_fullStr Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole Body
title_full_unstemmed Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole Body
title_short Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole Body
title_sort patient specific dosimetry phantoms using multichannel lddmm of the whole body
url http://dx.doi.org/10.1155/2011/481064
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