Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013–2015)
Purpose. In this study, we investigated the status of thyroid function and its association with metabolic risk factors in Korean adolescents. Methods. Among 2679 subjects aged 10–19 years who participated in the Korea National Health and Nutrition Examination Survey VI (2013–2015), 1067 adolescents...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6874395 |
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| author | Won Kyoung Cho Hyo-Kyoung Nam Jae Hyun Kim Young-Jun Rhie Sochung Chung Kee-Hyoung Lee Byung-Kyu Suh |
| author_facet | Won Kyoung Cho Hyo-Kyoung Nam Jae Hyun Kim Young-Jun Rhie Sochung Chung Kee-Hyoung Lee Byung-Kyu Suh |
| author_sort | Won Kyoung Cho |
| collection | DOAJ |
| description | Purpose. In this study, we investigated the status of thyroid function and its association with metabolic risk factors in Korean adolescents. Methods. Among 2679 subjects aged 10–19 years who participated in the Korea National Health and Nutrition Examination Survey VI (2013–2015), 1067 adolescents (M=559, F=508) with available data on free T4 (FT4) and thyroid-stimulating hormone (TSH) were included. Study participants were classified into normal weight [body mass index (BMI) below 85th percentile, 80.7%], overweight (85th ≤ BMI< 95th percentile, 8.7%), and obesity (BMI ≥ 95th percentile, 10.6%). Results. With increasing levels of BMI category, the means of TSH increased (2.73 ± 0.06, 2.77 ± 0.02, and 3.24 ± 0.22 mIU/L, P=0.031) and FT4 decreased (1.30 ± 0.01, 1.26 ± 0.02, and 1.25 ± 0.02 ng/mL, P=0.001). Positive linear associations were observed between TSH and BMI z-score (P=0.031), waist circumference (P=0.013), waist-height ratio (P=0.002), systolic blood pressure (P=0.001), total cholesterol (P=0.008), and triglyceride (P=0.002) after adjusting for age and sex. With per-unit increase in TSH, the odds ratios of having abdominal obesity (OR = 1.18, 95% CI, 1.01–1.38) and triglyceride ≥ 150 mg/dL (OR = 1.18, 95% CI, 1.04–1.34) were significantly increased after adjusting for age, sex, and BMI. Conclusions. In adolescents with obesity, TSH was higher and FT4 was lower than in adolescents with normal weight. Hyperthyrotropinemia was associated with abnormal metabolic risk factors including abdominal obesity and elevated triglyceride. |
| format | Article |
| id | doaj-art-cfa09f498cfc4a0f90829162a8fa4667 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-cfa09f498cfc4a0f90829162a8fa46672025-02-03T01:25:22ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/68743956874395Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013–2015)Won Kyoung Cho0Hyo-Kyoung Nam1Jae Hyun Kim2Young-Jun Rhie3Sochung Chung4Kee-Hyoung Lee5Byung-Kyu Suh6Department of Pediatrics, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Gyeonggi-do 16247, Republic of KoreaDepartment of Pediatrics, College of Medicine, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu Seoul 08308, Republic of KoreaDepartment of Pediatrics, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, Gyeonggi-do 13620, Republic of KoreaDepartment of Pediatrics, College of Medicine, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan, Gyeonggi-do 15355, Republic of KoreaDepartment of Pediatrics, College of Medicine, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 05030, Republic of KoreaDepartment of Pediatrics, College of Medicine, Korea University Anam Hospital, 73 Inchon-ro, Seongbuk-gu Seoul 02841, Republic of KoreaDepartment of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of KoreaPurpose. In this study, we investigated the status of thyroid function and its association with metabolic risk factors in Korean adolescents. Methods. Among 2679 subjects aged 10–19 years who participated in the Korea National Health and Nutrition Examination Survey VI (2013–2015), 1067 adolescents (M=559, F=508) with available data on free T4 (FT4) and thyroid-stimulating hormone (TSH) were included. Study participants were classified into normal weight [body mass index (BMI) below 85th percentile, 80.7%], overweight (85th ≤ BMI< 95th percentile, 8.7%), and obesity (BMI ≥ 95th percentile, 10.6%). Results. With increasing levels of BMI category, the means of TSH increased (2.73 ± 0.06, 2.77 ± 0.02, and 3.24 ± 0.22 mIU/L, P=0.031) and FT4 decreased (1.30 ± 0.01, 1.26 ± 0.02, and 1.25 ± 0.02 ng/mL, P=0.001). Positive linear associations were observed between TSH and BMI z-score (P=0.031), waist circumference (P=0.013), waist-height ratio (P=0.002), systolic blood pressure (P=0.001), total cholesterol (P=0.008), and triglyceride (P=0.002) after adjusting for age and sex. With per-unit increase in TSH, the odds ratios of having abdominal obesity (OR = 1.18, 95% CI, 1.01–1.38) and triglyceride ≥ 150 mg/dL (OR = 1.18, 95% CI, 1.04–1.34) were significantly increased after adjusting for age, sex, and BMI. Conclusions. In adolescents with obesity, TSH was higher and FT4 was lower than in adolescents with normal weight. Hyperthyrotropinemia was associated with abnormal metabolic risk factors including abdominal obesity and elevated triglyceride.http://dx.doi.org/10.1155/2018/6874395 |
| spellingShingle | Won Kyoung Cho Hyo-Kyoung Nam Jae Hyun Kim Young-Jun Rhie Sochung Chung Kee-Hyoung Lee Byung-Kyu Suh Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013–2015) International Journal of Endocrinology |
| title | Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013–2015) |
| title_full | Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013–2015) |
| title_fullStr | Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013–2015) |
| title_full_unstemmed | Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013–2015) |
| title_short | Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013–2015) |
| title_sort | thyroid function in korean adolescents with obesity results from the korea national health and nutrition examination survey vi 2013 2015 |
| url | http://dx.doi.org/10.1155/2018/6874395 |
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