Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication
Summary:. Abdominoplasty is a common aesthetic procedure, and ischemic complications are rare, particularly in nonsmokers. We present 2 cases of ischemic complications in nonsmoking patients treated with fremanezumab, a biologic medication for severe migraines. A 55-year-old woman underwent lipoabdo...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-01-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006449 |
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| author | Reetta Tuominen, MD, PhD Virve Koljonen, MD, PhD |
| author_facet | Reetta Tuominen, MD, PhD Virve Koljonen, MD, PhD |
| author_sort | Reetta Tuominen, MD, PhD |
| collection | DOAJ |
| description | Summary:. Abdominoplasty is a common aesthetic procedure, and ischemic complications are rare, particularly in nonsmokers. We present 2 cases of ischemic complications in nonsmoking patients treated with fremanezumab, a biologic medication for severe migraines. A 55-year-old woman underwent lipoabdominoplasty on December 18, 2023. At the 16-day postoperative follow-up, demarcated necrosis was observed beneath the wound tape, and secondary direct closure was performed 6 weeks later. She had been using fremanezumab for 4 years. A 47-year-old woman underwent abdominoplasty on April 23, 2024, with moderate dissection and liposuction to the flanks. Signs of abdominal flap ischemia were evident in the operating room, and treatment for the Raynaud phenomenon was initiated immediately. The ischemia demarcated over 2 weeks, and secondary direct closure was performed 3 weeks postoperatively. She had been using fremanezumab for two months. Calcitonin gene-related peptide antagonists are potent medications for severe migraine with few contraindications. Fremanezumab may affect peripheral circulation, potentially increasing the risk of surgical complications. |
| format | Article |
| id | doaj-art-cf9dcf9b62e547cdbbcc1dd3c7be5c9f |
| institution | Kabale University |
| issn | 2169-7574 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj-art-cf9dcf9b62e547cdbbcc1dd3c7be5c9f2025-01-24T09:19:58ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742025-01-01131e644910.1097/GOX.0000000000006449202501000-00022Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine MedicationReetta Tuominen, MD, PhD0Virve Koljonen, MD, PhD1From the * Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, FinlandFrom the * Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, FinlandSummary:. Abdominoplasty is a common aesthetic procedure, and ischemic complications are rare, particularly in nonsmokers. We present 2 cases of ischemic complications in nonsmoking patients treated with fremanezumab, a biologic medication for severe migraines. A 55-year-old woman underwent lipoabdominoplasty on December 18, 2023. At the 16-day postoperative follow-up, demarcated necrosis was observed beneath the wound tape, and secondary direct closure was performed 6 weeks later. She had been using fremanezumab for 4 years. A 47-year-old woman underwent abdominoplasty on April 23, 2024, with moderate dissection and liposuction to the flanks. Signs of abdominal flap ischemia were evident in the operating room, and treatment for the Raynaud phenomenon was initiated immediately. The ischemia demarcated over 2 weeks, and secondary direct closure was performed 3 weeks postoperatively. She had been using fremanezumab for two months. Calcitonin gene-related peptide antagonists are potent medications for severe migraine with few contraindications. Fremanezumab may affect peripheral circulation, potentially increasing the risk of surgical complications.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006449 |
| spellingShingle | Reetta Tuominen, MD, PhD Virve Koljonen, MD, PhD Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication Plastic and Reconstructive Surgery, Global Open |
| title | Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication |
| title_full | Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication |
| title_fullStr | Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication |
| title_full_unstemmed | Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication |
| title_short | Two Cases of Ischemic Complications in Abdominoplasty After Use of a New Biologic Migraine Medication |
| title_sort | two cases of ischemic complications in abdominoplasty after use of a new biologic migraine medication |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006449 |
| work_keys_str_mv | AT reettatuominenmdphd twocasesofischemiccomplicationsinabdominoplastyafteruseofanewbiologicmigrainemedication AT virvekoljonenmdphd twocasesofischemiccomplicationsinabdominoplastyafteruseofanewbiologicmigrainemedication |