Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort study
Objective To investigate associations between concussion and the risk of follow-up diagnoses of attention-deficit hyperactivity disorder (ADHD), mood and anxiety disorders (MADs), dementia and Parkinson’s disease.Design A retrospective population-based cohort study.Setting Administrative health data...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-07-01
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| Series: | Family Medicine and Community Health |
| Online Access: | https://fmch.bmj.com/content/8/3/e000390.full |
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| author | Marc P Morissette Heather J Prior Robert B Tate John Wade Jeff R S Leiter |
| author_facet | Marc P Morissette Heather J Prior Robert B Tate John Wade Jeff R S Leiter |
| author_sort | Marc P Morissette |
| collection | DOAJ |
| description | Objective To investigate associations between concussion and the risk of follow-up diagnoses of attention-deficit hyperactivity disorder (ADHD), mood and anxiety disorders (MADs), dementia and Parkinson’s disease.Design A retrospective population-based cohort study.Setting Administrative health data for the Province of Manitoba between 1990–1991 and 2014–2015.Participants A total of 47 483 individuals were diagnosed with a concussion using International Classification of Diseases (ICD) codes (ICD-9-CM: 850; ICD-10-CA: S06.0). All concussed subjects were matched with healthy controls at a 3:1 ratio based on age, sex and geographical location. Associations between concussion and conditions of interest diagnosed later in life were assessed using a stratified Cox proportional hazards regression model, with adjustments for socioeconomic status and pre-existing medical conditions.Results 28 021 men (mean age ±SD, 25±18 years) and 19 462 women (30±21 years) were included in the concussion group, while 81 871 men (25±18 years) and 57 159 women (30±21 years) were included in the matched control group. Concussion was associated with adjusted hazard ratios of 1.39 (95% CI 1.32 to 1.46, p<0.001) for ADHD, 1.72 (95% CI 1.69 to 1.76; p<0.001) for MADs, 1.72 (95% CI 1.61 to 1.84; p<0.001) for dementia and 1.57 (95% CI 1.41 to 1.75; p<0.001) for Parkinson’s disease.Conclusion Concussion was associated with an increased risk of diagnosis for all four conditions of interest later in life. |
| format | Article |
| id | doaj-art-cf9d09b7baf04b3d98a78831449c13cf |
| institution | OA Journals |
| issn | 2305-6983 2009-8774 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Family Medicine and Community Health |
| spelling | doaj-art-cf9d09b7baf04b3d98a78831449c13cf2025-08-20T02:12:14ZengBMJ Publishing GroupFamily Medicine and Community Health2305-69832009-87742020-07-018310.1136/fmch-2020-000390Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort studyMarc P Morissette0Heather J Prior1Robert B Tate2John Wade3Jeff R S Leiter4Pan Am Clinic Foundation, Winnipeg, Manitoba, CanadaManitoba Centre for Health Policy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, CanadaCommunity Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, CanadaRady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, CanadaFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, CanadaObjective To investigate associations between concussion and the risk of follow-up diagnoses of attention-deficit hyperactivity disorder (ADHD), mood and anxiety disorders (MADs), dementia and Parkinson’s disease.Design A retrospective population-based cohort study.Setting Administrative health data for the Province of Manitoba between 1990–1991 and 2014–2015.Participants A total of 47 483 individuals were diagnosed with a concussion using International Classification of Diseases (ICD) codes (ICD-9-CM: 850; ICD-10-CA: S06.0). All concussed subjects were matched with healthy controls at a 3:1 ratio based on age, sex and geographical location. Associations between concussion and conditions of interest diagnosed later in life were assessed using a stratified Cox proportional hazards regression model, with adjustments for socioeconomic status and pre-existing medical conditions.Results 28 021 men (mean age ±SD, 25±18 years) and 19 462 women (30±21 years) were included in the concussion group, while 81 871 men (25±18 years) and 57 159 women (30±21 years) were included in the matched control group. Concussion was associated with adjusted hazard ratios of 1.39 (95% CI 1.32 to 1.46, p<0.001) for ADHD, 1.72 (95% CI 1.69 to 1.76; p<0.001) for MADs, 1.72 (95% CI 1.61 to 1.84; p<0.001) for dementia and 1.57 (95% CI 1.41 to 1.75; p<0.001) for Parkinson’s disease.Conclusion Concussion was associated with an increased risk of diagnosis for all four conditions of interest later in life.https://fmch.bmj.com/content/8/3/e000390.full |
| spellingShingle | Marc P Morissette Heather J Prior Robert B Tate John Wade Jeff R S Leiter Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort study Family Medicine and Community Health |
| title | Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort study |
| title_full | Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort study |
| title_fullStr | Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort study |
| title_full_unstemmed | Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort study |
| title_short | Associations between concussion and risk of diagnosis of psychological and neurological disorders: a retrospective population-based cohort study |
| title_sort | associations between concussion and risk of diagnosis of psychological and neurological disorders a retrospective population based cohort study |
| url | https://fmch.bmj.com/content/8/3/e000390.full |
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