Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

Integrins are cell surface receptors that mediate the interactions of cells with their surroundings and play essential roles in cell adhesion, migration, and homeostasis. Eight of the 24 integrins bind to the tripeptide Arg-Gly-Asp (RGD) motif in their extracellular ligands, comprising the RGD-bindi...

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Bibliographic Details
Main Authors: Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A. Springer
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
RGD-binding integrin
yeast display
antibody screening
inhibitory antibody
function blocking
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2365891
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