Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite
Abstract The integration of the addressability of DNA nanostructures and the electronic sensitivity of sp2 carbon‐based materials presents a promising avenue for the development of powerful sensitive biodevices for detecting biological signals and substances with high sensitivity. Essential to this...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-02-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202400557 |
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| author | Yanjing Gao Jielin Chen Jiangbo Liu Mingqiang Li Yichun Wang |
| author_facet | Yanjing Gao Jielin Chen Jiangbo Liu Mingqiang Li Yichun Wang |
| author_sort | Yanjing Gao |
| collection | DOAJ |
| description | Abstract The integration of the addressability of DNA nanostructures and the electronic sensitivity of sp2 carbon‐based materials presents a promising avenue for the development of powerful sensitive biodevices for detecting biological signals and substances with high sensitivity. Essential to this prospect is the attainment of high‐shape fidelity immobilization of DNA nanostructures on these sp2 carbon substrates. However, it is challenging due to the stability of DNA nanostructures on these substrates. In this study, the adsorption behavior of DNA nanostructures is explored on a highly oriented pyrolytic graphite (HOPG) surface. The observations revealed a severe structural destabilization of DNA nanostructures upon interacting with bare HOPG. Immobilization of DNA nanostructures with high shape‐fidelity can be achieved by modifying the surface property of HOPG and enhancing the rigidity of DNA nanostructures. In addition, DNA tetrahedron origami is employed as a rigid, precise, and programmable three‐dimensional framework for controlled patterning of gold nanoparticles on HOPG surface, demonstrating the potential for constructing plasmonic devices and arranging other functional species on sp2 carbon‐based substrates for specific applications. This study shows the potential for customizable functionalization of sp2 carbon‐based substrates and tailored design of biodevices at the interface through integration with DNA nanostructures. |
| format | Article |
| id | doaj-art-cf96cd8b5f7a421ea7d3e00db5df7381 |
| institution | Kabale University |
| issn | 2196-7350 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj-art-cf96cd8b5f7a421ea7d3e00db5df73812025-02-03T13:24:06ZengWiley-VCHAdvanced Materials Interfaces2196-73502025-02-01123n/an/a10.1002/admi.202400557Deposition of DNA Nanostructures on Highly Oriented Pyrolytic GraphiteYanjing Gao0Jielin Chen1Jiangbo Liu2Mingqiang Li3Yichun Wang4Department of Chemical and Biomolecular Engineering University of Notre Dame Notre Dame IN 46556 USASchool of Chemistry and Chemical Engineering New Cornerstone Science Laboratory Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 ChinaSchool of Chemistry and Chemical Engineering New Cornerstone Science Laboratory Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 ChinaSchool of Chemistry and Chemical Engineering New Cornerstone Science Laboratory Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 ChinaDepartment of Chemical and Biomolecular Engineering University of Notre Dame Notre Dame IN 46556 USAAbstract The integration of the addressability of DNA nanostructures and the electronic sensitivity of sp2 carbon‐based materials presents a promising avenue for the development of powerful sensitive biodevices for detecting biological signals and substances with high sensitivity. Essential to this prospect is the attainment of high‐shape fidelity immobilization of DNA nanostructures on these sp2 carbon substrates. However, it is challenging due to the stability of DNA nanostructures on these substrates. In this study, the adsorption behavior of DNA nanostructures is explored on a highly oriented pyrolytic graphite (HOPG) surface. The observations revealed a severe structural destabilization of DNA nanostructures upon interacting with bare HOPG. Immobilization of DNA nanostructures with high shape‐fidelity can be achieved by modifying the surface property of HOPG and enhancing the rigidity of DNA nanostructures. In addition, DNA tetrahedron origami is employed as a rigid, precise, and programmable three‐dimensional framework for controlled patterning of gold nanoparticles on HOPG surface, demonstrating the potential for constructing plasmonic devices and arranging other functional species on sp2 carbon‐based substrates for specific applications. This study shows the potential for customizable functionalization of sp2 carbon‐based substrates and tailored design of biodevices at the interface through integration with DNA nanostructures.https://doi.org/10.1002/admi.202400557DNA nanostructureshigh‐shape fidelity immobilizationsp2 carbon‐based materials |
| spellingShingle | Yanjing Gao Jielin Chen Jiangbo Liu Mingqiang Li Yichun Wang Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite Advanced Materials Interfaces DNA nanostructures high‐shape fidelity immobilization sp2 carbon‐based materials |
| title | Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite |
| title_full | Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite |
| title_fullStr | Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite |
| title_full_unstemmed | Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite |
| title_short | Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite |
| title_sort | deposition of dna nanostructures on highly oriented pyrolytic graphite |
| topic | DNA nanostructures high‐shape fidelity immobilization sp2 carbon‐based materials |
| url | https://doi.org/10.1002/admi.202400557 |
| work_keys_str_mv | AT yanjinggao depositionofdnananostructuresonhighlyorientedpyrolyticgraphite AT jielinchen depositionofdnananostructuresonhighlyorientedpyrolyticgraphite AT jiangboliu depositionofdnananostructuresonhighlyorientedpyrolyticgraphite AT mingqiangli depositionofdnananostructuresonhighlyorientedpyrolyticgraphite AT yichunwang depositionofdnananostructuresonhighlyorientedpyrolyticgraphite |