Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus
ObjectiveThis study aimed to investigate the effect of mid-pregnancy lipid levels on adverse outcomes in women with gestational diabetes mellitus (GDM) under adequate glycemic control. Whether this effect is independent of factors such as blood glucose was also analyzed.MethodsWe retrospectively ana...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1545393/full |
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| author | Ru Zhao Ru Zhao Jun Hu Yuanqin Li Yuanqin Li Xuetao Chen Xuetao Chen Qian Wang Qian Wang Tingting Wu Tingting Wu Weihong Zhou Yan Bi Yan Bi Shanmei Shen Shanmei Shen Zhijuan Ge Zhijuan Ge |
| author_facet | Ru Zhao Ru Zhao Jun Hu Yuanqin Li Yuanqin Li Xuetao Chen Xuetao Chen Qian Wang Qian Wang Tingting Wu Tingting Wu Weihong Zhou Yan Bi Yan Bi Shanmei Shen Shanmei Shen Zhijuan Ge Zhijuan Ge |
| author_sort | Ru Zhao |
| collection | DOAJ |
| description | ObjectiveThis study aimed to investigate the effect of mid-pregnancy lipid levels on adverse outcomes in women with gestational diabetes mellitus (GDM) under adequate glycemic control. Whether this effect is independent of factors such as blood glucose was also analyzed.MethodsWe retrospectively analyzed 1,001 women with normal glucose tolerance (NGT) and 1,078 women with GDM under adequate glycemic control from 2015 to 2024. Logistic regression analysis was used to explore the relationship between blood lipids and adverse outcomes. Those with GDM were further classified according to their pre-pregnancy body mass index (BMI), gestational weight gain, glycosylated hemoglobin A1c (HbA1c), and fasting blood glucose (FBG). An interaction model between triglyceride (TG) and pre-pregnancy BMI, gestational weight gain, HbA1c, and FBG on adverse outcomes was constructed.ResultsIn GDM, high levels of TG were independent risk factors for preeclampsia (OR = 1.51, 95%CI = 1.18–1.93), preterm birth (OR = 1.68, 95%CI = 1.30–2.18), macrosomia (OR = 1.48, 95%CI = 1.14–1.92), postpartum hemorrhage (OR = 1.33, 95%CI = 1.10–1.61), and intrauterine fetal distress (OR = 1.68, 95%CI = 1.13–2.51). Furthermore, TG had a greater impact on GDM women than on NGT women. In addition, in GDM, high levels of TG were independent risk factors for the above adverse outcomes in the subgroups of pre-pregnancy BMI, gestational weight gain, HbA1c, and FBG (interaction p > 0.05).ConclusionsHigh levels of TG promoted the occurrence of preeclampsia, preterm birth, macrosomia, postpartum hemorrhage, and intrauterine fetal distress in women with GDM. Furthermore, TG had a greater effect on adverse outcomes in GDM than in NGT women. |
| format | Article |
| id | doaj-art-cf8ee0fbb0644fb2912ba1f487f35be1 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-cf8ee0fbb0644fb2912ba1f487f35be12025-08-20T02:16:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-04-011610.3389/fendo.2025.15453931545393Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitusRu Zhao0Ru Zhao1Jun Hu2Yuanqin Li3Yuanqin Li4Xuetao Chen5Xuetao Chen6Qian Wang7Qian Wang8Tingting Wu9Tingting Wu10Weihong Zhou11Yan Bi12Yan Bi13Shanmei Shen14Shanmei Shen15Zhijuan Ge16Zhijuan Ge17Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, ChinaDepartment of Health Management Centre, Huadong Sanatorium, Wuxi, ChinaDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, ChinaDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, ChinaDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, ChinaDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, ChinaDepartment of Health Management Centre, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, ChinaDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, ChinaDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, ChinaObjectiveThis study aimed to investigate the effect of mid-pregnancy lipid levels on adverse outcomes in women with gestational diabetes mellitus (GDM) under adequate glycemic control. Whether this effect is independent of factors such as blood glucose was also analyzed.MethodsWe retrospectively analyzed 1,001 women with normal glucose tolerance (NGT) and 1,078 women with GDM under adequate glycemic control from 2015 to 2024. Logistic regression analysis was used to explore the relationship between blood lipids and adverse outcomes. Those with GDM were further classified according to their pre-pregnancy body mass index (BMI), gestational weight gain, glycosylated hemoglobin A1c (HbA1c), and fasting blood glucose (FBG). An interaction model between triglyceride (TG) and pre-pregnancy BMI, gestational weight gain, HbA1c, and FBG on adverse outcomes was constructed.ResultsIn GDM, high levels of TG were independent risk factors for preeclampsia (OR = 1.51, 95%CI = 1.18–1.93), preterm birth (OR = 1.68, 95%CI = 1.30–2.18), macrosomia (OR = 1.48, 95%CI = 1.14–1.92), postpartum hemorrhage (OR = 1.33, 95%CI = 1.10–1.61), and intrauterine fetal distress (OR = 1.68, 95%CI = 1.13–2.51). Furthermore, TG had a greater impact on GDM women than on NGT women. In addition, in GDM, high levels of TG were independent risk factors for the above adverse outcomes in the subgroups of pre-pregnancy BMI, gestational weight gain, HbA1c, and FBG (interaction p > 0.05).ConclusionsHigh levels of TG promoted the occurrence of preeclampsia, preterm birth, macrosomia, postpartum hemorrhage, and intrauterine fetal distress in women with GDM. Furthermore, TG had a greater effect on adverse outcomes in GDM than in NGT women.https://www.frontiersin.org/articles/10.3389/fendo.2025.1545393/fulllipidsgestational diabetes mellitusadverse outcomesrisk factorspregnancy |
| spellingShingle | Ru Zhao Ru Zhao Jun Hu Yuanqin Li Yuanqin Li Xuetao Chen Xuetao Chen Qian Wang Qian Wang Tingting Wu Tingting Wu Weihong Zhou Yan Bi Yan Bi Shanmei Shen Shanmei Shen Zhijuan Ge Zhijuan Ge Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus Frontiers in Endocrinology lipids gestational diabetes mellitus adverse outcomes risk factors pregnancy |
| title | Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus |
| title_full | Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus |
| title_fullStr | Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus |
| title_full_unstemmed | Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus |
| title_short | Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus |
| title_sort | influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus |
| topic | lipids gestational diabetes mellitus adverse outcomes risk factors pregnancy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1545393/full |
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