Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression
Germ cell protein expression in melanoma has been shown to correlate with malignancy, severity of disease and to serve as an immunologic target for therapy. However, very little is known about the role that germ cell proteins play in cancer development. Unique germ cell pathways include those involv...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/621968 |
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| author | Ashley M. Rosa Nitika Dabas Diana M. Byrnes Mark S. Eller James M. Grichnik |
| author_facet | Ashley M. Rosa Nitika Dabas Diana M. Byrnes Mark S. Eller James M. Grichnik |
| author_sort | Ashley M. Rosa |
| collection | DOAJ |
| description | Germ cell protein expression in melanoma has been shown to correlate with malignancy, severity of disease and to serve as an immunologic target for therapy. However, very little is known about the role that germ cell proteins play in cancer development. Unique germ cell pathways include those involved in immortalization, genetic evolution, and energy metabolism. There is an ever increasing recognition that within tumors there is a subpopulation of cells with stem-cell-like characteristics that play a role in driving tumorgenesis. Stem cell and germ cell biology is intertwined. Given the enormous potential and known expression of germ cell proteins in melanoma, it is possible that they represent a largely untapped resource that may play a fundamental role in tumor development and progression. The purpose of this paper is to provide an update on the current value of germ cell protein expression in melanoma diagnosis, prognosis, and therapy, as well as to review critical germ cell pathways and discuss the potential roles these pathways may play in malignant transformation. |
| format | Article |
| id | doaj-art-cf86a3d3672c4ef7aa61c139289f75f8 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-cf86a3d3672c4ef7aa61c139289f75f82025-02-03T07:25:17ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/621968621968Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on ExpressionAshley M. Rosa0Nitika Dabas1Diana M. Byrnes2Mark S. Eller3James M. Grichnik4Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USAGerm cell protein expression in melanoma has been shown to correlate with malignancy, severity of disease and to serve as an immunologic target for therapy. However, very little is known about the role that germ cell proteins play in cancer development. Unique germ cell pathways include those involved in immortalization, genetic evolution, and energy metabolism. There is an ever increasing recognition that within tumors there is a subpopulation of cells with stem-cell-like characteristics that play a role in driving tumorgenesis. Stem cell and germ cell biology is intertwined. Given the enormous potential and known expression of germ cell proteins in melanoma, it is possible that they represent a largely untapped resource that may play a fundamental role in tumor development and progression. The purpose of this paper is to provide an update on the current value of germ cell protein expression in melanoma diagnosis, prognosis, and therapy, as well as to review critical germ cell pathways and discuss the potential roles these pathways may play in malignant transformation.http://dx.doi.org/10.1155/2012/621968 |
| spellingShingle | Ashley M. Rosa Nitika Dabas Diana M. Byrnes Mark S. Eller James M. Grichnik Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression Journal of Skin Cancer |
| title | Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression |
| title_full | Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression |
| title_fullStr | Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression |
| title_full_unstemmed | Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression |
| title_short | Germ Cell Proteins in Melanoma: Prognosis, Diagnosis, Treatment, and Theories on Expression |
| title_sort | germ cell proteins in melanoma prognosis diagnosis treatment and theories on expression |
| url | http://dx.doi.org/10.1155/2012/621968 |
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